[CuZnBr2(N,N'-bis(salicylidene)-1,3-propanediamine-2H)(N,N-dimethylformamide)] | 1326634-62-1

• 英文名称: [CuZnBr2(N,N'-bis(salicylidene)-1,3-propanediamine-2H)(N,N-dimethylformamide)]
• 英文别名: [CuBr2(N,N'-bis(salicylidene)-1,3-propanediamine-2H)(DMF)]
• CAS: 1326634-62-1
• 化学式: C₂₀H₂₃Br₂CuN₃O₃Zn
• 分子量: 642.165
• InChiKey: QETDNGUNLVNUDW-VSXIBYRUSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) perchlorate hexahydrate 、 N,N'-二亚水杨基-1,3-二氨基丙烷 、 N,N-二甲基甲酰胺 、 zinc dibromide 以 甲醇 为溶剂， 以73%的产率得到[CuZnBr2(N,N'-bis(salicylidene)-1,3-propanediamine-2H)(N,N-dimethylformamide)]
  参考文献：
  名称：

  Preparation and structural characterization of hetero-dinuclear Schiff base copper(II)–zinc(II) complexes and their inhibition studies on Helicobacter pylori urease

  摘要：

  A series of hetero-dinuclear Cu-II-Zn-II complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L-3, L-4 and L-5 are the deprotonated forms of N,N'-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N'-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N'-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N'-bis(salicylidene)1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 mu M. The molecular docking study of the complexes with the Helicobacter pylori urease was performed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.05.048