4-Benzyl-1-propyl-piperidin-4-ol | 884497-71-6

• 英文名称: 4-Benzyl-1-propyl-piperidin-4-ol
• 英文别名: 4-(Phenylmethyl)-1-propyl-4-piperidinol；4-benzyl-1-propylpiperidin-4-ol
• CAS: 884497-71-6
• 化学式: C₁₅H₂₃NO
• mdl: MFCD13166871
• 分子量: 233.354
• InChiKey: LVKWYEZGBIBUQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Benzyl-1-propyl-piperidin-4-ol 、 苯 在 三氟甲磺酸 作用下， 反应 2.0h， 以89%的产率得到4-Diphenylmethyl-1-n-propylpiperidin
  参考文献：
  名称：

  Charge Migration in Dicationic Electrophiles and Its Application to the Synthesis of Aza-polycyclic Aromatic Compounds

  摘要：

  Superacid-promoted reactions of dicationic electrophiles have been studied, and the positive charge centers are found to migrate apart in a predictable manner. Using isotopic labeling the charge migration is found in one system to occur through successive deprotonation-reprotonation steps. The charge migration chemistry is the basis for new general synthetic route to aza-polycyclic aromatic compounds.

  DOI：

  10.1021/ol060125u
• 作为产物：
  描述：

  N-丙基-4-哌啶酮 、 苄基氯化镁 以 四氢呋喃 、 乙醚 为溶剂， 反应 2.0h， 生成 4-Benzyl-1-propyl-piperidin-4-ol
  参考文献：
  名称：

  Charge Migration in Dicationic Electrophiles and Its Application to the Synthesis of Aza-polycyclic Aromatic Compounds

  摘要：

  Superacid-promoted reactions of dicationic electrophiles have been studied, and the positive charge centers are found to migrate apart in a predictable manner. Using isotopic labeling the charge migration is found in one system to occur through successive deprotonation-reprotonation steps. The charge migration chemistry is the basis for new general synthetic route to aza-polycyclic aromatic compounds.

  DOI：

  10.1021/ol060125u