[Pt(4,4'-bithiazole)Cl4] | 1334551-54-0

• 英文名称: [Pt(4,4'-bithiazole)Cl4]
• 英文别名: [Pt(4bt)Cl4]
• CAS: 1334551-54-0
• 化学式: C₆H₄Cl₄N₂PtS₂
• 分子量: 505.135
• InChiKey: KUDHKQBRTWAVJU-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  4,4′-bithiazole 、 dihydrogen hexachloroplatinate(IV) hexahydrate 以 甲醇 为溶剂， 以75.2%的产率得到[Pt(4,4'-bithiazole)Cl4]
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity of a series of tetrachloridoplatinum(IV) complexes

  摘要：

  Two platinum(IV) complexes, [Pt(4bt)Cl(4)] (4) and [Pt(dpyam)Cl(4)].DMF (5) (where 4bt is 4,4'-bithiazole and dpyam is 2,2'-dipyridylamine) were prepared from the reaction of H(2)PtCl(6)center dot 6H(2)O with 4,4'-bithiazole and 2,2'-dipyridylamine, respectively, in methanol. Both complexes were fully characterized and their structures were determined by the X-ray diffraction method. These complexes have a bidentate nitrogenous ligand with four chloride anions attached to a Pt(IV) metal in a distorted octahedral environment. These complexes along with three previously reported analogous complexes were used for in vitro cytotoxicity evaluation against four cultures, NIH-3T3, Caco-2, HT-29 and T47D by MTT assay. The methyl group position in the ligand plays an important role in the cytotoxicity of relevant compounds in different cultures. Interestingly, in some cases, the IC(50) values of the new complexes were higher for normal cells but lower against cancer cells in comparison with cisplatin, especially in T47D (breast ductal carcinoma). (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.07.022