[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 (copper(II))2 (chloride)2] | 907997-08-4

• 英文名称: [(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 (copper(II))2 (chloride)2]
• 英文别名: [(propafenone(1-))2 copper(II)2 (chloride)2]
• CAS: 907997-08-4
• 化学式: C₄₂H₅₂Cl₂Cu₂N₂O₆
• 分子量: 878.883
• InChiKey: GUFLMPYFLUTVGE-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 盐酸普罗帕酮 在 NaOH 作用下， 以 甲醇 为溶剂， 以60%的产率得到[(1-[2-[2-oxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone(1-))2 (copper(II))2 (chloride)2]
  参考文献：
  名称：

  Complexes of 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone (propafenone) with copper(II): Crystal structure of the mononuclear Cu(II) complex with propafenone

  摘要：

  Two new copper(II) complexes with the antiarrythmic drug propafenone (HPr) have been synthesized: the mononuclear complex CuPr2 (1) and the binuclear one Cu2Pr2Cl2 (2) and have been studied using electronic, IR and EPR spectra, magnetochemical, thermogravimetric and single-crystal X-ray diffraction methods. In the mononuclear complex 1, copper(II) is coordinated bidentately with the NH and deprotonated OH groups of two drug molecules forming a nearly square-planar structure of the type CuL2, with a CuN2O2 chromophore. In complex 2 each copper atom is coordinated with one N atom from one ligand, one terminal chlorine atom and two oxygen atoms from two different ligand molecules which serve as bridges in the formation of the binuclear complex 2. Measurable antiferromagnetic interactions between the two paramagnetic Cu(II) centers are responsible for some interesting magnetic properties. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2006.01.027