| 1346931-59-6

• CAS: 1346931-59-6
• 化学式: C₂₉H₂₄N₃O₃PRu
• 分子量: 594.572
• InChiKey: DUOZPSIBIMMBNY-UHFFFAOYSA-M

反应信息

• 作为产物：
  描述：

  cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate 、 7,13-Bis[tert-butyl(dimethyl)silyl]-3,13,24-triazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1,4(9),5,7,10,15,17,19,21,23-decaene-12,14-dione 、 三甲基膦 在 N,N-diisopropylethylamine 、 TBAF 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 以36%的产率得到
  参考文献：
  名称：

  P-donor ligand containing ruthenium half-sandwich complexes as protein kinase inhibitors

  摘要：

  Metal complexes have emerged as promising and novel scaffolds for the design of enzyme inhibitors. Reported herein are the design, synthesis, and evaluation of protein kinase inhibition properties of pyridocarbazole half-sandwich complexes containing P-donor ligands. The nature of the monodentate P-donor ligand has a strong effect on protein kinase binding properties, most likely due to a direct interaction with the glycine-rich loop in the ATP-binding site. We furthermore discovered that PMe3 pyridocarbazole complexes are interesting lead structures for the design of potent inhibitors for the protein kinase TrkA for which we obtained a nanomolar organometallic inhibitor. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.07.032