[14C]ethyl iodide | 55676-72-7

• 英文名称: [14C]ethyl iodide
• 英文别名: <¹⁴C2>-1-Iod-ethan；iodo-[1,2-¹⁴C]ethane
• CAS: 55676-72-7
• 化学式: C₂H₅I
• 分子量: 159.944
• InChiKey: HVTICUPFWKNHNG-XPULMUKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  3.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  [14C]ethyl iodide 、 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography

  摘要：

  In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel F-18-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[C-14]ethylpiperidin-3- and 4-ylmethyl esters, N-[C-14]ethylpiperidin-4-ylmethyl butyrate was selected as a lead for F-18-labeling, affording N-[F-18]fluoroethylpiperidin-4-ylmethyl butyrate. The F-18-labeled butyrate showed the required properties for in vivo BChE measurement, that is, the lipophilic nature of the authentic ester, high specificity to B3ChE, a moderate hydrolysis rate, and the hydrophilic nature of the metabolite. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.080