K(Pt(digly)Cl3)*H2O | 336193-63-6

• 英文名称: K(Pt(digly)Cl3)*H2O
• CAS: 336193-63-6
• 化学式: C₄H₆Cl₃N₂O₃Pt*H₂O*K
• 分子量: 488.656
• InChiKey: QEKWDKWXDKSJAL-UHFFFAOYSA-I

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  盐酸 、 K(Pt(digly)Cl3)*H2O 以 水 为溶剂， 以99%的产率得到K(Pt(Hdigly)Cl4)*H2O
  参考文献：
  名称：

  Platinum(IV) Complexes with Dipeptide. X-ray Crystal Structure, ¹⁹⁵Pt NMR Spectra, and Their Inhibitory Glucose Metabolism Activity in Candida albicans

  摘要：

  Three dipeptide complexes of the form K[Pt-IV(dipep)Cl-3] and two complexes of the form K[Pt-IV(Hdipep)Cl-4 were newly prepared and isolated. The platinum(IV) complexes containing the dipeptide were obtained directly by adding KI to H2CPtCl6] solution. The reaction using KI was rapidly completed and provided analytically purl yellow products in the form of K[Pt(dipeptide)Cl-3] for H(2)digly, H(2)gly alpha -ala, H(2)alpha -alagly and H(2)di alpha -ala. The K[Pt-IV(digly)Cl-3] complex crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions a = 10.540(3) Angstrom ,b = 13.835(3) Angstrom, c = 8.123(3) Angstrom, beta = 97.01(2)degrees, Z = 4. The crystal data represented the first report of a Pt(IV) complex with a deprotonated peptide, and this complex has the rare iminol type diglycine(2-) coordinating to Pt(IV) with the bond lengths of the C2-N1 (amide) bond (1.285(13) Angstrom). The Pt-195 NMR peaks of-the K[Pt-IV (dipep)Cl-3 and the K[Pt-IV(Hdipep)Cl-4] complexes appeared at about 270 ppm and at about -130 ppm, respectively, and were predicted for a given set of ligand atoms. While the K[Pt-IV(x-gly)Cl-3] complexes, where x denotes the glycine or alpha -alanine moieties, were easily reduced to the corresponding platinum(II) complexes, the K[Pt-IV(x alpha -ala)Cl-3] complexes were not reduced, but the Cl- ion was substituted for OH- ion in the reaction solution. The E([Pt(digly)Cl-3] and K[Pt(gly-L-alpha -ala)Cl-3] complexes inhibited the growth of Candida albicans, and the antifungal activities were 3- to 4-fold higher than those of cisplatin. The metabolism of glucose in C. albicans was strongly inhibited by K[Pt(digly)Cl-3] and K[Pt(gly-L-alpha -ala)Cl-3]but not by the antifungal agent fluconazole.

  DOI：

  10.1021/ic000686w
• 作为产物：
  描述：

  dihydrogen hexachloroplatinate(IV) hexahydrate 、 potassium iodide 、 双甘肽 在 KOH 、 AgNO₃ 作用下， 以 水 为溶剂， 以53%的产率得到K(Pt(digly)Cl3)*H2O
  参考文献：
  名称：

  Platinum(IV) Complexes with Dipeptide. X-ray Crystal Structure, ¹⁹⁵Pt NMR Spectra, and Their Inhibitory Glucose Metabolism Activity in Candida albicans

  摘要：

  Three dipeptide complexes of the form K[Pt-IV(dipep)Cl-3] and two complexes of the form K[Pt-IV(Hdipep)Cl-4 were newly prepared and isolated. The platinum(IV) complexes containing the dipeptide were obtained directly by adding KI to H2CPtCl6] solution. The reaction using KI was rapidly completed and provided analytically purl yellow products in the form of K[Pt(dipeptide)Cl-3] for H(2)digly, H(2)gly alpha -ala, H(2)alpha -alagly and H(2)di alpha -ala. The K[Pt-IV(digly)Cl-3] complex crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions a = 10.540(3) Angstrom ,b = 13.835(3) Angstrom, c = 8.123(3) Angstrom, beta = 97.01(2)degrees, Z = 4. The crystal data represented the first report of a Pt(IV) complex with a deprotonated peptide, and this complex has the rare iminol type diglycine(2-) coordinating to Pt(IV) with the bond lengths of the C2-N1 (amide) bond (1.285(13) Angstrom). The Pt-195 NMR peaks of-the K[Pt-IV (dipep)Cl-3 and the K[Pt-IV(Hdipep)Cl-4] complexes appeared at about 270 ppm and at about -130 ppm, respectively, and were predicted for a given set of ligand atoms. While the K[Pt-IV(x-gly)Cl-3] complexes, where x denotes the glycine or alpha -alanine moieties, were easily reduced to the corresponding platinum(II) complexes, the K[Pt-IV(x alpha -ala)Cl-3] complexes were not reduced, but the Cl- ion was substituted for OH- ion in the reaction solution. The E([Pt(digly)Cl-3] and K[Pt(gly-L-alpha -ala)Cl-3] complexes inhibited the growth of Candida albicans, and the antifungal activities were 3- to 4-fold higher than those of cisplatin. The metabolism of glucose in C. albicans was strongly inhibited by K[Pt(digly)Cl-3] and K[Pt(gly-L-alpha -ala)Cl-3]but not by the antifungal agent fluconazole.

  DOI：

  10.1021/ic000686w