CuCl(1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylate)(4'-(4-methylphenyl)-2,2':6',2''-terpyridine) | 1356397-60-8

• 英文名称: CuCl(1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylate)(4'-(4-methylphenyl)-2,2':6',2''-terpyridine)
• CAS: 1356397-60-8
• 化学式: C₃₈H₃₄ClCuFN₆O₃
• 分子量: 740.724
• InChiKey: DGTYGYQSQPXNCP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 4′-(4-甲基苯基)-2,2′:6′,2′′-三吡啶 、 诺氟沙星 在 CH₃ONa 作用下， 以 甲醇 为溶剂， 以68.3%的产率得到CuCl(1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylate)(4'-(4-methylphenyl)-2,2':6',2''-terpyridine)
  参考文献：
  名称：

  DNA interaction, in vitro antimicrobial and SOD-like activity of copper(II) complexes with norfloxacin and terpyridines

  摘要：

  The novel octahedral copper(II) complexes with the second generation fluoroquinolone, norfloxacin and terpyridine derivatives were prepared and characterized. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity. Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA whereas the cleavage efficacy of the complexes towards pUC19 DNA was determined by electrophoresis in presence of ethidium bromide. SOD mimic behaviour was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT/NADH/PMS), and was found to have good antioxidant activity. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.11.022