cis-[PtCl2(isopropylamine)(1-methylpyrazole)] | 881880-62-2

• 英文名称: cis-[PtCl2(isopropylamine)(1-methylpyrazole)]
• 英文别名: cis-[PtCl2(iPam)(Mepz)]
• CAS: 881880-62-2；913069-57-5
• 化学式: C₇H₁₅Cl₂N₃Pt
• 分子量: 407.202
• InChiKey: OATNIKRBOGCVBI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  鸟苷酸 、 cis-[PtCl2(isopropylamine)(1-methylpyrazole)] 在 NaClO₄ 作用下， 以 N,N-二甲基甲酰胺-d7 、 重水 为溶剂， 生成
  参考文献：
  名称：

  In vitro antitumor activity and interaction with DNA model bases of cis-[PtCl2(iPram)(azole)] complexes and comparison with their trans analogues

  摘要：

  Asymmetric cis-platinum(II) complexes with isopropylamine and two different azole ligands were synthesized and characterized with different techniques. In addition, for one of the complexes the X-ray structure was determined. Cytotoxicity tests using several human tumor cell lines, including the cisplatin-sensitive cell line A2780 and its cisplatin-resistant analogue. These results were compared with the results obtained for the trans isomers of the presented complexes and a relation between the structure and the activity was established. It was found that complexes with cis geometry are less active than their trans analogues, in particular in the resistant cell line A2780R. However, complex 1 can overcome cisplatin resistance to a certain extent. In the interaction with GMP, the asymmetric cis-Pt(II) complexes react with similar rates as their trans analogues and they behave as bifunctional species. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.06.012
• 作为产物：
  描述：

  cis-[PtI2(isopropylamine)(1-methylpyrazole)] 、 potassium chloride 在 AgNO₃ 作用下， 以 水 为溶剂， 以36%的产率得到cis-[PtCl2(isopropylamine)(1-methylpyrazole)]
  参考文献：
  名称：

  In vitro antitumor activity and interaction with DNA model bases of cis-[PtCl2(iPram)(azole)] complexes and comparison with their trans analogues

  摘要：

  Asymmetric cis-platinum(II) complexes with isopropylamine and two different azole ligands were synthesized and characterized with different techniques. In addition, for one of the complexes the X-ray structure was determined. Cytotoxicity tests using several human tumor cell lines, including the cisplatin-sensitive cell line A2780 and its cisplatin-resistant analogue. These results were compared with the results obtained for the trans isomers of the presented complexes and a relation between the structure and the activity was established. It was found that complexes with cis geometry are less active than their trans analogues, in particular in the resistant cell line A2780R. However, complex 1 can overcome cisplatin resistance to a certain extent. In the interaction with GMP, the asymmetric cis-Pt(II) complexes react with similar rates as their trans analogues and they behave as bifunctional species. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.06.012