| 1411785-15-3

• CAS: 1411785-15-3
• 化学式: C₂₃H₂₄Cl₂MnN₄O₅Zn*H₂O
• 分子量: 645.717
• InChiKey: LJKHBNFHXOJZNR-NPIDOWHHSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  甲醇 、 N,N′-bis(3-formyl-5-chlorosalicylidene)ethylenediimine 、 manganese (II) acetate tetrahydrate 、 zinc(II) acetate dihydrate 、 1,3-二氨基-2-羟基丙烷 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 14.0h， 以46%的产率得到
  参考文献：
  名称：

  Structure, DNA binding and cleavage of a new Zn(II)Mn(II) macrocyclic complex

  摘要：

  A new heterodinuclear complex of an unsymmetrical macrocycle [ZnMnL(CH3O)(2)]center dot H2O has been synthesized by the cyclocondensation between N,N'-bis(3-formyl-5-chlorosalicylidene)ethylenediimine and 2-hydroxyl-1,3-propanediamine in the presence of the metal ions, and characterized by elemental analyses, IR spectra and X-ray determination. The interactions of the complex with DNA have been investigated by UV absorption, fluorescence spectroscopy, viscosity measurements and electrochemical studies. Absorption spectroscopic investigation reveals that the complex has good binding propensity to calf thymus DNA by intercalation with a binding constant of 2.52 x 10(5) M-1. Fluorescence spectroscopy shows that the complex can displace ethidium bromide and bind to DNA, with a quenching constant of 4.37 x 10(3) M-1. The agarose gel electrophoresis studies show that pBR322 plasmid DNA can be transformed to nicked form and linear form in air by the complex. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.08.029