α-bromo-α-1H-1,2,4-triazol-1-yl-acetylferrocene | 874651-65-7

• 英文名称: α-bromo-α-1H-1,2,4-triazol-1-yl-acetylferrocene
• 英文别名: 2-bromo-2-(1H-1,2,4-triazol-1-yl)-acetyl-ferrocene；2-bromo-2-(1H-1,2,4-triazol-1-yl)acetylferrocene；2-bromo-2(1H-1,2,4-triazol-1-yl)acetylferrocene
• CAS: 874651-65-7
• 化学式: C₁₄H₁₂BrFeN₃O
• 分子量: 374.02
• InChiKey: YNZBUSSISWORQN-KLQYNRQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  α-bromo-α-1H-1,2,4-triazol-1-yl-acetylferrocene 、 2-萘酚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以81.6%的产率得到2-(2-naphthenoxy)-1-feroocenyl-2-(1H-1,2,4-trizol-1-yl)ethanone
  参考文献：
  名称：

  Synthesis, characterization, and biological evaluation of novel ferrocene-triadimefon analogues

  摘要：

  In order to improve biological behavior of the 1H-1,2,4-triazole derivatives, a series of new ferrocene-analogues of commercial triadimefon were synthesized and their antifungal and plant growth regulatory activities evaluated. These organometallic analogues showed lower antifungal activity than parent triadimefon, but exhibited promising plant growth regulatory activity. (c) 2005 Published by Elsevier B.V.

  DOI：

  10.1016/j.jorganchem.2005.11.029
• 作为产物：
  描述：

  N-溴代丁二酰亚胺(NBS) 、 α-(1H-1,2,4-triazol-1-yl)-acetyl-ferrocene 在 n-BuLi 、 diisopropylamine 、 Me₃SiCl 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以83%的产率得到α-bromo-α-1H-1,2,4-triazol-1-yl-acetylferrocene
  参考文献：
  名称：

  新型含二茂铁基噻唑亚胺衍生物的合成及生物活性研究

  摘要：

  通过取代苯甲醛的缩合反应合成了一系列新型的N-取代的亚苄基-4-亚铁茂基-5-（1 H -1,2,4-三唑-1-基）-1,3-噻唑-2-胺衍生物用2-氨基-4-二茂铁基-5-（1 H -1,2,4-三唑-1-基）-1,3-噻唑进行表征，并通过1 H NMR，X射线衍射和元素分析进行​​表征。生物测定的结果表明，某些标题化合物表现出一定程度的植物生长调节和抗真菌活性。

  DOI：

  10.1016/j.jorganchem.2006.10.059

文献信息

• Synthesis and Biological Evaluation of Novel Ferrocene‐Substituted Triadimefon‐ and Triadimenol‐Analogues
  作者：Zhong Jin、Yan Hu、Ling Shao、Jianxin Fang

  DOI：10.1080/15533170701608791

  日期：2007.10.1

  To search potent antifungal agents, a series of new ferrocene-containing analogues of commercial fungicides, namely triadimefon and triadimenol, were synthesized by replacement of the tert-butyl group of original agents with ferrocene group. These organometallic derivatives were found to be unactive against various fungi, but show promising plant growth regulatory activity.
• Synthesis and Evaluation of Novel Ferrocenyl Thiazole Derivatives as Anticancer Agents
  作者：Ling Shao、Xin Zhou、Yan Hu、Zhong Jin、Jianbing Liu、Jian‐xin Fang

  DOI：10.1080/15533170600651405

  日期：2006.5.1

  Novel ferrocenyl-containing thiazole derivatives have been synthesized from 2-amino-4-ferrocenyl-5-(1H-1,2,4-triazole-1-yl)-1,3-thiazole and substituted benzoyl chloride. The structures of these compounds have been characterized by H-1 NMR, elemental analysis and X-ray diffraction analysis. Evaluation of anticancer activities showed that some of them possessed some degree of anticancer activity.