cis-ammine(4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum (II) | 325148-41-2

• 英文名称: cis-ammine(4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum (II)
• CAS: 325148-41-2；170309-76-9
• 化学式: C₉H₂₂ClIN₃OPt
• 分子量: 545.731
• InChiKey: HLRSJQQZUZLSHJ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  cis-ammine(4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum (II) 在 phenylhydrazine 作用下， 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Long-Range Distance Constraints in Platinated Nucleotides: Structure Determination of the 5' Orientational Isomer of cis-[Pt(NH3)(4-aminoTEMPO){d(GpG)}]+ from Combined Paramagnetic and Diamagnetic NMR Constraints with Molecular Modeling

  摘要：

  The compound cis-[Pt(NH3)(4-aminoTEMPO)ClI] (7) is a paramagnetic analogue of the anticancer drug cisplatin and of cis-[Pt(NH3)(C6H11NH2)Cl-2] (1), a major metabolite of a recently developed, orally administered derivative. The bifunctional mixed amine complex 7 and a monofunctional triamine complex, trans-[Pt(NH3)(2)(4-aminoTEMPO)Cl]NO3 (8), were synthesized to provide localized unpaired electron spin density for use in NMR spectral studies of their polynucleotide adducts. Compounds 7 and 8 readily coordinate to the N(7) positions of guanosine nucleosides, as revealed by H-1, P-31, and Pt-195 NMR spectroscopy. The NMR spectra were selectively broadened owing to distance-dependent relaxation from the unpaired electron localized on the nitroxyl radical of the 4-aminoTEMPO ligand. Platination of d(GpG) by the mixed amine complex 7 afforded two orientational isomers which differed with respect to the positioning of the 4-aminoTEMPO group toward either the 3' or 5' side of the phosphodiester linkage. The purified orientational isomers were readily distinguished by selective broadening of the H-1 NMR resonances of the 3' and 5' deoxyribose rings. The minimum energy solution structure for the 5' orientational isomer of the platinated dinucleotide cis-[Pt(NH3)(4-aminoTEMPO)(d(GpG)}](+) (13) was determined by NMR methods including combined diamagnetic (J coupling constants) and paramagnetic (electron-H-1, P-31 distances) constraints. Moreover, with the paramagnetic spin probe, we have been able to obtain the first observable NMR distance constraints for determining the configuration of the zeta or alpha torsion angles in any oligonucleotide. Dynamics trajectories (200 ps) for 13 demonstrated that only computations including paramagnetic distance constraints could determine the zeta(-), alpha(-) conformation of the phosphodiester linkage and the conformation of the 4-aminoTEMPO ligand. These NMR data and computational methods demonstrate the utility of long-range paramagnetic distance constraints in elucidating the NMR solution structures of DNA modified by cisplatin analogues.

  DOI：

  10.1021/ja00148a012
• 作为产物：
  描述：

  sodium iodide 、 4-氨基-TEMPO 、 K{PtaCl3}*H2O 以 水 为溶剂， 生成 cis-ammine(4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum (II)
  参考文献：
  名称：

  Synthesis, structure, and biological activity of mixed-ligand platinum(II) complexes with aminonitroxides

  摘要：

  Mixed-ligand platinum complexes cis-Pt-11((RNH2)-N-6)(NH3)X-2 and cis-Pt-11((RNH2)-N-5)(NH3)X-2 (R-6 is 2,2,6,6-tetramethyl-4-piperidyl-1-oxyl and R-5 is 2,2,5,5-tetramethyl-3-pyrrolidinyl-1-oxyl) were synthesized by either the reaction of aminonitroxides RNH2 with Na[Pt-11(NH3)CI2I] generated in situ (for X-2 = ClI) or by replacement of the iodo-chloro ligands in Cis-Pt-11(RNH2)(NH3)Cll by dichloro and oxalato ligands. The complexes obtained were characterized by elemental analysis and by IR, UV, and ESR spectra. For Cis-Pt-11((RNH2)-N-5)(NH3)Cl-2, crystal and molecular structures were determined by X-ray diffraction analysis. Cisplatin accelerates autooxidation of methyl linoleate and the platinum nitroxide complexes synthesized exhibit antioxidant properties. The rate of isolated DNA binding with the new complexes is almost as high as that for cisplatin. cis-Pt-11((RNH2)-N-6)(NH3)Cl-2 exhibits the highest antitumor activity. The high antitumor activity of platinum nitroxide complexes shows that the possible "radical component" is not a crucial factor in the cytotoxic action of cisplatin.

  DOI：

  10.1007/bf02495168