| 66962-62-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 66962-62-7；67010-17-7
• 化学式: C₅₀H₆₁N₅O₁₄
• 分子量: 956.059
• InChiKey: NOCZWLMOSBLQNZ-PHEKIHNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.67
• 重原子数：
  69.0
• 可旋转键数：
  18.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  241.78
• 氢给体数：
  6.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  4-N-acylfortimicins b and the preparation of fortimicin a from fortimicin B

  摘要：

  Selective 4-N-acylation of fortimicin B (2) has been accomplished by 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (4) followed by hydrogenolysis of the N-protecting benzyloxycarbonyl groups. In this manner, fortimicin B was converted into fortimicin A (1), and a series of 4-N-acylfortimicins B (3) was prepared for antibacterial assay. The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter.

  DOI：

  10.1016/s0008-6215(00)85134-4
• 作为产物：
  描述：

  1,2',6',2''-tetra-N-benzyloxycarbonyl-4-N-methyl-fortimicin A 在 碳酸氢钠 、 1-羟基苯并三唑一水物 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 28.0h， 生成
  参考文献：
  名称：

  4-N-acylfortimicins b and the preparation of fortimicin a from fortimicin B

  摘要：

  Selective 4-N-acylation of fortimicin B (2) has been accomplished by 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (4) followed by hydrogenolysis of the N-protecting benzyloxycarbonyl groups. In this manner, fortimicin B was converted into fortimicin A (1), and a series of 4-N-acylfortimicins B (3) was prepared for antibacterial assay. The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter.

  DOI：

  10.1016/s0008-6215(00)85134-4