2-methyl-thieno[3,2-d]thiazole | 23421-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并噻唑类
• 英文名称: 2-methyl-thieno[3,2-d]thiazole
• 英文别名: 2-Methyl-thieno[3,2-d]thiazol；2-Methylthieno[3,2-d]thiazole；2-Methyl-thieno[3,2-d]thiazole；2-methylthieno[3,2-d][1,3]thiazole
• CAS: 23421-09-2
• 化学式: C₆H₅NS₂
• 分子量: 155.244
• InChiKey: USYIMWPSAXPXRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-thieno[3,2-d]thiazole 在 三氯异氰尿酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  通过有机锂加成硫使稠合噻吩开环

  摘要：

  有机锂试剂可以与被氯原子取代并与另一个芳族系统稠合的噻吩的硫原子加成，在 -78 °C 下，得到邻位取代的芳基硫化物。

  DOI：

  10.1055/s-1998-1674
• 作为产物：
  描述：

  N-(3-噻吩基)乙酰胺 在 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 生成 2-methyl-thieno[3,2-d]thiazole
  参考文献：
  名称：

  Shirjakow, Khimicheskaya Nauka i Promyshlennost, 1959, vol. 4, p. 680

  摘要：

  DOI：

文献信息

• 2-[3H-THIAZOL-2-YLIDINEMETHYL]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE
  申请人：Brown Robert

  公开号：US20090247579A1

  公开（公告）日：2009-10-01

  The present invention pertains to certain 2-[3H-thiazol-2-ylidinemethyl]pyridine compounds and analogs thereof, which, inter alia, inhibit cell proliferation, treat cancer, etc., and more specifically to compounds of the following formula, wherein R A1 , R A2 , R A3 , R A4 , R B1 , R B2 , R NA , R NB , and X − are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative conditions such as cancer, etc.

  本发明涉及某些2-[3H-噻唑-2-基亚甲基]吡啶化合物及其类似物，其中包括抑制细胞增殖、治疗癌症等作用，更具体地涉及以下式的化合物，其中R A1 、R A2 、R A3 、R A4 、R B1 、R B2 、R NA 、R NB 和X − 如本文所定义： 本发明还涉及包含这种化合物的药物组合物，以及在体外和体内使用这种化合物和组合物来抑制细胞增殖，并用于治疗癌症等增生性疾病。
• Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of
  申请人：Merck Frosst Canada, Inc.

  公开号：US05374635A1

  公开（公告）日：1994-12-20

  Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomemlar nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

  具有以下化学式的化合物：##STR1## 是白三烯生物合成的抑制剂。这些化合物可用作抗哮喘、抗过敏、抗炎和细胞保护剂。它们还可用于治疗心绞痛、脑痉挛、肾小球肾炎、肝炎、内毒素血症、葡萄膜炎、移植排斥反应，并且可预防动脉粥样硬化斑块的形成。
• Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
  申请人：Merck Frosst Canada, Inc.

  公开号：US05350760A1

  公开（公告）日：1994-09-27

  Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

  具有化学式I: ##STR1## 的化合物是白三烯行动的拮抗剂。这些化合物可用作抗哮喘、抗过敏、抗炎和细胞保护剂。它们还可用于治疗心绞痛、脑痉挛、肾小球肾炎、肝炎、内毒素血症、葡萄膜炎和移植排斥反应。
• COLORING COMPOSITION, DICHROIC DYE COMPOUND, LIGHT ABSORPTION ANISOTROPIC FILM, LAMINATE, AND IMAGE DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20190071571A1

  公开（公告）日：2019-03-07

  A dichroic dye compound has an excellent alignment property when used in a light absorption anisotropic film, and has excellent solubility. A coloring composition contains the dichroic dye compound having a structure represented by Formula (1). In Formula (1), A and B represent a crosslinkable group, a and b are 0 or 1, and a+b is not less than 1. L 1 and L 2 represent a monovalent substituent, a single bond, or a divalent linking group. Each of Ar 1 to Ar 3 represents an aromatic hydrocarbon group or heterocyclic group. R 1 to R 3 represent a monovalent substituent. k represents an integer of 1 to 4. n1, n2, and n3 represent an integer of 0 to 4. In a case where k is 1, n1+n2+n3 is not less than 0, and in a case where k is not less than 2, n1+n2+n3 is not less than 1.

  一种二色性染料化合物在光吸收各向异性薄膜中具有优异的取向性能，并具有优异的溶解性。一种着色组合物包含具有由公式（1）表示的结构的二色性染料化合物。在公式（1）中，A和B表示可交联基团，a和b为0或1，a+b不小于1。L1和L2表示一价取代基、单键或二价连接基团。Ar1到Ar3中的每一个表示芳香碳氢基团或杂环基团。R1到R3表示一价取代基。k表示1到4的整数。n1、n2和n3表示0到4的整数。在k为1的情况下，n1+n2+n3不小于0，在k不小于2的情况下，n1+n2+n3不小于1。
• Method for manufacturing optical laminate, optical laminate, and image display device
  申请人：FUJIFILM Corporation

  公开号：US11378838B2

  公开（公告）日：2022-07-05

  An object of the present invention is to provide a method for manufacturing an optical laminate in which an alignment defect is less likely to occur in a light-absorbing anisotropic layer even in a case where a surface of a photo-alignment layer is rubbed; an optical laminate; and an image display device. The method for manufacturing an optical laminate according to an embodiment of the present invention is a method for manufacturing an optical laminate in which an optical laminate including a photo-alignment layer and a light-absorbing anisotropic layer and having a front transmittance of 60% or less is produced and which includes a photo-alignment layer formation step of forming a photo-alignment layer on a polymer film, and a light-absorbing anisotropic layer formation step of applying a liquid crystal composition containing a dichroic substance and a high-molecular liquid crystalline compound onto the photo-alignment layer to form a light-absorbing anisotropic layer.

  本发明的目的是提供一种光学层压板的制造方法，在该方法中，即使在光对准层的表面被摩擦的情况下，光吸收各向异性层也不太可能出现对准缺陷；还提供一种光学层压板；以及一种图像显示装置。根据本发明一个实施例的光学层压板制造方法是一种制造光学层压板的方法，在该方法中，生产出包括光对准层和光吸收各向异性层且前透射率小于或等于 60% 的光学层压板，该方法包括在聚合物薄膜上形成光对准层的光对准层形成步骤、光吸收各向异性层形成步骤：将含有二向色物质和高分子液晶化合物的液晶组合物涂在光对准层上，形成光吸收各向异性层。