Ca钙调素(钙调蛋白) | 377752-08-4

• 分子结构分类: 转移酶 - 转移含磷基团 - 蛋白丝氨酸/苏氨酸激酶
• 中文名称: Ca钙调素(钙调蛋白)
• 中文别名: CA钙调素(钙调蛋白)；2H,6H-噁唑并[5,4,3-ij]喹啉-2-酮,7-羟基-8,9-二(1-甲基乙氧基)-
• 英文名称: non-specific serine/threonine protein kinase
• 英文别名: A-kinase；AP50 kinase；ATP-protein transphosphorylase；calcium-dependent protein kinase C；calcium/phospholipid-dependent protein kinase；cAMP-dependent protein kinase；cAMP-dependent protein kinase A；casein kinase；casein kinase (phosphorylating)；casein kinase 2；casein kinase I；casein kinase II；cGMP-dependent protein kinase；CK-2；CKI；CKII；cyclic AMP-dependent protein kinase；cyclic AMP-dependent protein kinase A；cyclic monophosphate-dependent protein kinase；cyclic nucleotide-dependent protein kinase；cyclin-dependent kinase；cytidine 3',5'-cyclic monophosphate-responsive protein kinase；dsk1；glycogen synthase a kinase；glycogen synthase kinase；HIPK2；Hpr kinase；hydroxyalkyl-protein kinase；M phase-specific cdc2 kinase；mitogen-activated S6 kinase；p82 kinase；phosphorylase b kinase kinase；PKA；protein glutamyl kinase；protein kinase (phosphorylating)；protein kinase A；protein kinase CK2；protein kinase p58；protein phosphokinase；protein serine kinase；protein serine-threonine kinase；protein-aspartyl kinase；protein-cysteine kinase；protein-serine kinase；Prp4 protein kinase；Raf kinase；Raf-1；ribosomal protein S6 kinase II；ribosomal S6 protein kinase；serine kinase；serine protein kinase；serine-specific protein kinase；serine(threonine) protein kinase；serine/threonine protein kinase；STK32；T-antigen kinase；threonine-specific protein kinase；twitchin kinase；type-2 casein kinase；betaIIPKC；epsilon PKC；Wee 1-like kinase；Wee-kinase；WEE1Hu
• CAS: 377752-08-4；191808-15-8；52660-18-1；9026-43-1；90698-26-3；37278-10-7；340830-03-7；389133-24-8

反应信息

• 作为试剂：
  描述：

  Cou-Aoc-GRTGRRFSYP-amide 在 Ca钙调素(钙调蛋白) 、 GST-tagged 14-3-3τ plasmid 、 ATP 、 magnesium chloride 、 Cleland's reagent 、 acid green anthraquinone N 2S 作用下， 反应 30.0h， 生成
  参考文献：
  名称：

  Suborganelle Sensing of Mitochondrial cAMP-Dependent Protein Kinase Activity

  摘要：

  A fluorescent sensor of protein kinase activity has been developed and used to characterize the compartmentalized location of cAMP-dependent protein kinase activity in mitochondria. The sensor functions via a phosphorylation-induced release of a quencher from a peptide-based substrate, producing a 150-fold enhancement in fluorescence. The quenching phenomenon transpires via interaction of the quencher with Arg residues positioned on the peptide substrate. Although the cAMP-dependent protein kinase is known to be present in mitochondria, the relative amount of enzyme positioned in the major compartments (outer membrane, intermembrane space, and the matrix) of the organelle is unclear. The fluorescent sensor developed in this study was used to reveal the relative matrix/intermembrane space/outer membrane (85:6:9) distribution of PKA in bovine heart mitochondria.

  DOI：

  10.1021/ja909652q