| 1039038-09-9

• CAS: 1039038-09-9
• 化学式: C₁₇H₂₅NO
• 分子量: 259.392
• InChiKey: FEUZMIJQVFASBV-CQSZACIVSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium diacetate 碘苯二乙酸 、 碘 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以70%的产率得到(S)-4-tert-butyl-2-(1-(2-iodophenyl)-2-methylpropan-2-yl)-4,5-dihydrooxazole
  参考文献：
  名称：

  Remote C–H bond functionalization reveals the distance-dependent isotope effect

  摘要：

  Iodination of remote aryl C-H bonds has been achieved using palladium acetate as the catalyst and iodoacetate (IOAc) as the oxidant. Systematic kinetic isotope studies imply a mechanistic regime shift as the number of bonds separating the directing heteroatom and the target C-H bond increases. Both isotope and electronic effects observed in remote C-H bond activation are consistent with an electrophilic palladation pathway in which the initial palladation is slower than the C-H bond cleavage. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.026
• 作为产物：
  描述：

  在 三苯基膦 作用下， 生成
  参考文献：
  名称：

  Remote C–H bond functionalization reveals the distance-dependent isotope effect

  摘要：

  Iodination of remote aryl C-H bonds has been achieved using palladium acetate as the catalyst and iodoacetate (IOAc) as the oxidant. Systematic kinetic isotope studies imply a mechanistic regime shift as the number of bonds separating the directing heteroatom and the target C-H bond increases. Both isotope and electronic effects observed in remote C-H bond activation are consistent with an electrophilic palladation pathway in which the initial palladation is slower than the C-H bond cleavage. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.026