| 228726-56-5

• CAS: 228726-56-5
• 化学式: NTc
• 分子量: 113.007
• InChiKey: QNCKTQOZCDJWPF-IEOVAKBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.01
• 重原子数：
  2.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.79
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  、 sodium 4-(3-nitropyridin-2-yl)piperazine-1-carbodithioate 以 aq. phosphate buffer 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  99mTc 标记的 1-(2-吡啶基) 哌嗪衍生物作为 5HT7 受体放射性配体的合成与评价

  摘要：

  多形性胶质母细胞瘤 (GBM) 是人类中枢神经系统最具侵袭性的肿瘤之一。GBM 过度表达 5-羟色胺 7 受体 (5-HT 7 Rs)；因此，本研究旨在开发5-HT 7 R靶向放射性示踪剂。芳基哌嗪衍生物可作为5-HT 7 R的配体。因此，合成了化合物6和7作为1-(3-硝基吡啶-2-基)哌嗪衍生物，并以99m TcN 2+为核进行放射性标记。放射性标记的6和7 ( 99m TcN-[ 6 ] 和99m TcN-[ 7]) 以高放射化学纯度 (RCP > 96%) 制备。它们对 U-87 MG 细胞系 5-HT 7 R 表现出高亲和力。99m TcN-[ 7 ]的计算 K i低于99m TcN- [ 6 ]（14.85 ± 0.32 对 22.57 ± 0.73 nM），后者表明99m TcN-[ 7 ] 对 5-HT 7 R具有更高的亲和力。分子对接研究也证实了这些放射性示踪剂与 5-HT

  DOI：

  10.1016/j.bioorg.2023.106486

文献信息

• Preparation and evaluation of a 99mTcN–PNP complex of sanazole analogue for detecting tumor hypoxia
  作者：Anupam Mathur、Madhava B. Mallia、Sharmila Banerjee、H.D. Sarma、M.R.A. Pillai

  DOI：10.1016/j.bmcl.2012.12.079

  日期：2013.3

  A sanazole derivative, having a favorable single electron reduction potential (SERP) value compared to that of misonidazole, was synthesized and radiolabeled with [(TcN)-Tc-99m(PNP)] precursor to evaluate its potential as a hypoxia imaging agent. The complex, which was lipophilic, could be prepared in good yields and challenging studies with cysteine showed stability of the complex against trans-chelation. However, despite being lipophilic as well as possessing favorable SERP value, biodistribution studies of this complex in fibrosarcoma tumor bearing Swiss mice showed low uptake in tumor. This observation is possibly attributed to fast clearance of the complex from blood, whereby the complex spends insufficient time in tumor to get reduced and trapped. Though uptake in tumor was low, slow clearance of activity from tumor suggests reduction and trapping of the complex in hypoxic cells. The present Tc-99m-complex demonstrated acceptable values of tumor to blood (TBR) and tumor to muscle (TMR) ratios. However, low uptake in tumor which may not be indicative of the actual hypoxic status of the tumor, limit the utility of the complex to detect tumor hypoxia. (c) 2013 Elsevier Ltd. All rights reserved.