trans-[RuCl₂(1H-pyrazole)₄]Cl | 866530-72-5

• 英文名称: trans-[RuCl₂(1H-pyrazole)₄]Cl
• 英文别名: trans-[RuCl₂(Hpz)₄]Cl；trans-[Ru(III)Cl2(pyrazole)4]Cl
• CAS: 866530-72-5
• 化学式: C₁₂H₁₆Cl₂N₈Ru*Cl
• 分子量: 479.742
• InChiKey: IWRMEMUQMQPXSN-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  trans-[RuCl₂(1H-pyrazole)₄]Cl 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以67.8%的产率得到trans-[RuCl₂(1H-pyrazole)₄]
  参考文献：
  名称：

  簇中的亚硝酰基钌部分：三核线性 μ-羟基镁(II)-二钌(II)、μ3-氧化三核二铁(III)–钌(II) 和四核 μ4-氧化三镓(III)-钌(II)配合物

  摘要：

  钌亚硝酰基部分，{RuNO} 6 ，作为一氧化氮的潜在释放剂很重要，并且在配位化学中具有固有的意义。通常，{RuNO} 6存在于单核配合物中。在此，我们描述了包含该单元的几种多金属簇络合物的合成和表征。具体而言，异三核μ 3 -氧化物簇[Fe 2 RuCl 4 (μ 3 -O)(μ-OMe)(μ-pz) 2 (NO)(Hpz) 2 ] ( 6 )和[Fe 2 RuCl 3 (μ 3 -O)(μ-OMe)(μ-pz) 3 (MeOH)(NO)(Hpz)][Fe 2 RuCl 3 (μ 3 -O)(μ-OMe)(μ-pz) 3 (DMF) (NO)(Hpz)] ( 7 ·MeOH·2H 2 O) 和异四核 μ 4 -氧化配合物 [Ga 3 RuCl 3 (μ 4 -O)(μ-OMe) 3 (μ-pz) 4 (NO) ] ( 8 ) 由反式-[Ru(OH)(NO)(Hpz) 4 ]Cl 2 ( 5

  DOI：

  10.1021/acs.inorgchem.1c03011
• 作为产物：
  描述：

  吡唑 、 (pyrazolium)[trans-Ru(III)Cl4(pyrazole)2] 以 乙醇 、 水 为溶剂， 反应 7.0h， 以66.4%的产率得到trans-[RuCl₂(1H-pyrazole)₄]Cl
  参考文献：
  名称：

  簇中的亚硝酰基钌部分：三核线性 μ-羟基镁(II)-二钌(II)、μ3-氧化三核二铁(III)–钌(II) 和四核 μ4-氧化三镓(III)-钌(II)配合物

  摘要：

  钌亚硝酰基部分，{RuNO} 6 ，作为一氧化氮的潜在释放剂很重要，并且在配位化学中具有固有的意义。通常，{RuNO} 6存在于单核配合物中。在此，我们描述了包含该单元的几种多金属簇络合物的合成和表征。具体而言，异三核μ 3 -氧化物簇[Fe 2 RuCl 4 (μ 3 -O)(μ-OMe)(μ-pz) 2 (NO)(Hpz) 2 ] ( 6 )和[Fe 2 RuCl 3 (μ 3 -O)(μ-OMe)(μ-pz) 3 (MeOH)(NO)(Hpz)][Fe 2 RuCl 3 (μ 3 -O)(μ-OMe)(μ-pz) 3 (DMF) (NO)(Hpz)] ( 7 ·MeOH·2H 2 O) 和异四核 μ 4 -氧化配合物 [Ga 3 RuCl 3 (μ 4 -O)(μ-OMe) 3 (μ-pz) 4 (NO) ] ( 8 ) 由反式-[Ru(OH)(NO)(Hpz) 4 ]Cl 2 ( 5

  DOI：

  10.1021/acs.inorgchem.1c03011

文献信息

• Tuning of Redox Properties for the Design of Ruthenium Anticancer Drugs:  Part 2. Syntheses, Crystal Structures, and Electrochemistry of Potentially Antitumor [Ru^III/IICl_6-<i>_n</i>(Azole)<i>_n</i>]<i>^z</i> (<i>n</i> = 3, 4, 6) Complexes
  作者：Erwin Reisner、Vladimir B. Arion、Anna Eichinger、Norbert Kandler、Gerald Giester、Armando J. L. Pombeiro、Bernhard K. Keppler

  DOI：10.1021/ic0503737

  日期：2005.9.1

  A series of mixed chloro-azole ruthenium complexes with potential antitumor activity, viz., rner-[(RuCl3)-Cl-III(azole)(3)] (B), trans[(RuCl2)-Cl-III(azole)(4)]Cl (C), trans-[(RuCl2)-Cl-II(azole)(4)] (D), and [Ru-II(azole)(6)](SO3CF3)(2) (E), where azole = 1-butylimidazole (1), imidazole (2), benzimidazole (3), 1-methyl-1,2,4-triazole (4), 4-methylpyrazole (5), 1,2,4-triazole (6), pyrazole (7), and indazole (8), have been prepared as a further development of anticancer drugs with the general formula [RuCl4(azole)(2)](-) (A). These compounds were characterized by elemental analysis, IR spectroscopy, electronic spectra, electrospray mass spectrometry, and X-ray crystallography. The electrochemical behavior has been studied in detail in DMF, DMSO, and aqueous media using cyclic voltammetry, square wave voltammetry, and controlled potential electrolysis. Compounds B and a number of C complexes exhibit one Ru-III/Ru-II reduction, followed, at a sufficiently long time scale, by metal dechlorination on solvolysis. The redox potential values in organic media agree with those predicted by Lever's parametrization method, and the yet unknown E-L parameters were estimated for 1 (E-L = 0.06 V), 3 (E-L = 0.10 V), 4 (E-L = 0.17 V), and 5 (E-L = 0.18 V). The E-L values for the azole ligands 1-8 correlate linearly with their basicity (pK(a) value of the corresponding azolium acid H2L+). In addition, a logarithmic dependence between the homogeneous rate constants for the reductively induced stepwise replacement of chloro ligands by solvent molecules and the Ru-III/Ru-II redox potentials was observed. Lower E-1/2 values (higher net electron donor character of the ligands) result in enhanced kinetic rate constants of solvolysis upon reduction. The effect of the net charge on the Ru-III/Ru-II redox potentials in water is tentatively explained by the application of the Born equation. In addition, the pH-dependent electrochemical behavior of trans-[RuCl2(1,2,4-triazole)(4)]Cl is discussed.