[Co(N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis(2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide))Cl2] | 1383744-07-7

• 英文名称: [Co(N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis(2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide))Cl2]
• CAS: 1383744-07-7
• 化学式: C₂₄H₁₆Cl₂CoN₁₂O₂S₄
• 分子量: 762.633
• InChiKey: HHESBEBGYHUPHX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  cobalt(II) chloride hexahydrate 、 N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis(2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide) 以 乙醇 为溶剂， 生成 [Co(N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis(2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide))Cl2]
  参考文献：
  名称：

  Synthesis, DNA-binding, DNA-photonuclease profiling and antimicrobial activity of novel tetra-aza macrocyclic Ni(II), Co(II) and Cu(II) complexes constrained by thiadiazole

  摘要：

  A new tetra-aza macrocyclic ligand, L (C24H16N12O2S4) and its complexes of type, [MLCl2] and [CuL]Cl-2 (where M = Ni(II), Co(II); L = N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide}) were synthesized and characterized by the spectral and analytical techniques. An octahedral geometry has been proposed for Ni(II) and Co(II) complexes while Cu(II) complex exhibit a square planar geometry. All the synthesized metal complexes were screened for their in vitro antimicrobial activity against selected species of pathogenic bacteria and fungi. The binding property of the complexes with CT-DNA was studied by absorption spectral analysis, followed by viscosity measurement and thermal denaturation studies. The photo induced cleavage studies revealed that the complexes possess photonuclease property against pUC19 DNA under UV-visible irradiation. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.03.071