2-o-tolyloxy-ethylamine; hydrochloride | 313527-94-5

• 英文名称: 2-o-tolyloxy-ethylamine; hydrochloride
• 英文别名: 2-o-Tolyloxy-aethylamin; Hydrochlorid；1-(2-Aminoethoxy)-2-methylbenzene hydrochloride；2-(2-methylphenoxy)ethanamine;hydrochloride
• CAS: 313527-94-5
• 化学式: C₉H₁₃NO*ClH
• mdl: MFCD02667724
• 分子量: 187.669
• InChiKey: YKLDYAJWXJLMRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯基缩水甘油醚 、 2-o-tolyloxy-ethylamine; hydrochloride 在 sodium hydroxide 作用下， 以 丙醇 为溶剂， 生成 1-Phenoxy-3-(2-o-tolyloxy-ethylamino)-propan-2-ol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols

  摘要：

  The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.

  DOI：

  10.1021/jm00222a022

文献信息

• DE1913199
  申请人：——

  公开号：——

  公开（公告）日：——