1-(4-Bromo-phenyl)-2-(4-bromo-phenylamino)-ethanone | 146537-20-4

• 英文名称: 1-(4-Bromo-phenyl)-2-(4-bromo-phenylamino)-ethanone
• 英文别名: 2-(4-Bromoanilino)-1-(4-bromophenyl)ethanone
• CAS: 146537-20-4
• 化学式: C₁₄H₁₁Br₂NO
• 分子量: 369.055
• InChiKey: KSIZOQOSVLADDE-UHFFFAOYSA-N

物化性质

• 沸点：
  492.8±40.0 °C(predicted)
• 密度：
  1.699±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-Bromo-phenyl)-2-(4-bromo-phenylamino)-ethanone 在 sodium hydroxide 、 4-溴苯铵溴化物 、 zinc(II) chloride 作用下， 以 乙醇 、 苯 为溶剂， 反应 30.0h， 生成 1,4-Bis-(4-bromo-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles

  摘要：

  The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(92)90092-f
• 作为产物：
  描述：

  2,4'-二溴苯乙酮 、 4-溴苯胺 以 乙醇 为溶剂， 反应 4.0h， 以65%的产率得到1-(4-Bromo-phenyl)-2-(4-bromo-phenylamino)-ethanone
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles

  摘要：

  The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(92)90092-f