isobutyl-vinyl sulfone | 20356-81-4

• 英文名称: isobutyl-vinyl sulfone
• 英文别名: Isobutyl-vinyl-sulfon；1-Ethenylsulfonyl-2-methylpropane
• CAS: 20356-81-4
• 化学式: C₆H₁₂O₂S
• 分子量: 148.226
• InChiKey: OKLWWRGIZAWOJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  isobutyl-vinyl sulfone 、 alkaline earth salt of/the/ methylsulfuric acid 在 水 作用下， 生成 [3-(4-bromo-phenyl)-3-nitro-propyl]-isobutyl sulfone
  参考文献：
  名称：

  Buckley; Charlish; Rose, Journal of the Chemical Society, 1947, p. 1516

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 isobutyl-vinyl sulfone
  参考文献：
  名称：

  Preparation of vinyl sulfones

  摘要：

  公开号：

  US02474808A1

文献信息

• PYRROLOPYRIMIDINE AND PURINE DERIVATIVES
  申请人：Cheng Hengmiao

  公开号：US20130079324A1

  公开（公告）日：2013-03-28

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R 1 , R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中Q、T、V、W、X、Y、Z、环A、R1、R2、R3、R4、R5、R5a、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16、R17和m在此定义。这些新颖的吡咯嘧啶和嘌呤衍生物在哺乳动物中治疗异常细胞生长，如癌症方面具有用处。另外，本发明还涉及含有这些化合物的药物组合物，以及在哺乳动物中治疗异常细胞生长的方法。
• DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE
  申请人：Zhao Dr. Robert Yongxin

  公开号：US20150314017A1

  公开（公告）日：2015-11-05

  The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

  本发明涉及一种新型含有肼的二硫桥链连接剂，用于将化合物/细胞毒性药剂与细胞结合分子特异结合，通过连接细胞结合分子上的一对巯基。该发明还涉及制备这种连接剂的方法，以及在制备均一共轭物中使用这种连接剂的方法，以及将这些共轭物应用于治疗癌症、感染和自身免疫性疾病的方法。
• ERK INHIBITORS AND USES THEREOF
  申请人：Celgene Avilomics Research, Inc.

  公开号：US20140228322A1

  公开（公告）日：2014-08-14

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE
  申请人：Zhao Dr. Robert Yongxin

  公开号：US20150322155A1

  公开（公告）日：2015-11-12

  The present invention relates to novel acetylenedicarboxyl linkers used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

  本发明涉及用于将化合物/细胞毒性药剂与细胞结合分子特异结合的新型乙炔二羧酸酯连接剂，通过在细胞结合分子上连接硫醇成对的桥链。该发明还涉及制备此类连接剂的方法，以及在制备均一共轭物中使用此类连接剂的方法，以及在治疗癌症、感染和自身免疫性紊乱中应用这些共轭物的方法。
• Protein-Polymer-Drug Conjugates
  申请人：Yurkovetskiy Aleksandr

  公开号：US20120321583A1

  公开（公告）日：2012-12-20

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. L D and L P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种药物结合物。该结合物包括一种基于蛋白质的识别分子（PBRM）和一个聚合物载体，该载体被一个或多个-LD-D取代，基于蛋白质的识别分子通过LP连接到聚合物载体上。每个D的出现都是分子量≦5 kDa的治疗剂。LD和LP是连接治疗剂和PBRM到聚合物载体的连接剂。还公开了用于与PBRM结合形成聚合物-药物-PBRM结合物的聚合物支架，包括结合物的组成，其制备方法以及使用结合物或其组成物治疗各种疾病的方法。