cis-ammine(4-amino-2,2,6,6-tetramethylpiperidine)dichloroplatinum(II) | 780752-07-0

• 英文名称: cis-ammine(4-amino-2,2,6,6-tetramethylpiperidine)dichloroplatinum(II)
• CAS: 780752-07-0
• 化学式: C₉H₂₃Cl₂N₃Pt
• 分子量: 439.288
• InChiKey: AUVAMSYIULUTAC-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  cis-ammine(4-amino-2,2,6,6-tetramethylpiperidine)dichloroplatinum(II) 在 potassium tungstate H₂O₂ 作用下， 以 水 为溶剂， 生成 e-ammine-d-(4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl)-a,f-dihydroxo-b,c-dichloroplatinum(II)
  参考文献：
  名称：

  摘要：

  The platinum(IV) complexes cis,trans,cis-Pt-IV(RNH2)(NH3)(OH)(2)Cl-2, where R is 2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl (1) or 2,2,5,5-tetramethyl-1-oxyl-3-pyrrolidinyl (2), were prepared by oxidation of the corresponding cis-Pt-II(RNH2)(NH3)Cl-2 complexes with hydrogen peroxide. The reactions are catalyzed by tungstate salts, which makes it possible to carry out oxidation under mild conditions. The resulting complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectroscopy. The structure of complex 1 was established by X-ray diffraction analysis. Complex 1 exhibits the highest antitumor activity in an experimental tumor, viz., in P388 leukemia. The resistance of the tumor to this complex developed much slower than that to Cisplatin.

  DOI：

  10.1023/a:1023475319835
• 作为产物：
  描述：

  2,2,6,6-四甲基哌啶胺 以 水 为溶剂， 生成 cis-ammine(4-amino-2,2,6,6-tetramethylpiperidine)dichloroplatinum(II)
  参考文献：
  名称：

  摘要：

  The platinum(IV) complexes cis,trans,cis-Pt-IV(RNH2)(NH3)(OH)(2)Cl-2, where R is 2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl (1) or 2,2,5,5-tetramethyl-1-oxyl-3-pyrrolidinyl (2), were prepared by oxidation of the corresponding cis-Pt-II(RNH2)(NH3)Cl-2 complexes with hydrogen peroxide. The reactions are catalyzed by tungstate salts, which makes it possible to carry out oxidation under mild conditions. The resulting complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectroscopy. The structure of complex 1 was established by X-ray diffraction analysis. Complex 1 exhibits the highest antitumor activity in an experimental tumor, viz., in P388 leukemia. The resistance of the tumor to this complex developed much slower than that to Cisplatin.

  DOI：

  10.1023/a:1023475319835