(R)-3-(5-methyl-5H-indolo[3,2-b]quinolin-11-ylamino)propane-1,2-diol | 1029683-04-2

• 英文名称: (R)-3-(5-methyl-5H-indolo[3,2-b]quinolin-11-ylamino)propane-1,2-diol
• CAS: 1029683-04-2
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: IULCWNIGLAMHJD-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70.31
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (R)-3-(5-methyl-5H-indolo[3,2-b]quinolin-11-ylamino)propane-1,2-diol 、 4,4'-双甲氧基三苯甲基氯 在 4-二甲氨基吡啶 作用下， 以 吡啶 为溶剂， 反应 2.5h， 以28%的产率得到(R)-3-(5-methyl-5H-indolo[3,2-b]quinolin-11-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-ol
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074
• 作为产物：
  描述：

  (R)-3-氨基-1,2-丙二醇 、 11-chloro-5-methyl-5H-indolo[3,2-b]quinoline 以 乙二醇乙醚 为溶剂， 反应 0.17h， 以63%的产率得到(R)-3-(5-methyl-5H-indolo[3,2-b]quinolin-11-ylamino)propane-1,2-diol
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074