cis-[PtCl2(N-cyclohexyl-1,3-propanediamine)] | 114504-37-9

• 英文名称: cis-[PtCl2(N-cyclohexyl-1,3-propanediamine)]
• 英文别名: cis-[PtCl2(chpda)]
• CAS: 114504-37-9
• 化学式: C₉H₂₀Cl₂N₂Pt
• 分子量: 422.257
• InChiKey: ANWPCZAUKIRNKH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  cis-[PtCl2(N-cyclohexyl-1,3-propanediamine)] 、 水 、 双氧水 以 水 为溶剂， 以65%的产率得到cis,trans,cis-[PtCl2(OH)2(N-cyclohexyl-1,3-propanediamine)]*2H2O
  参考文献：
  名称：

  Chelate vs monodentate amine effects. Direct comparison of bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) (JM216) with its N-cyclohexyl-1,3-propanediamine analogue

  摘要：

  In order to investigate the chelate effects on physicochemical properties including antitumor activity, new cis,trans,cis,-[(PtCl2L2)-Cl-IV(chpda)] complexes (L = OH, OCOCH3; chpda = N-cyclohexyl-1,3-propanediamine) have been synthesized and characterized. The crystal structure of cis,trans,cis-[(PtCl2)-Cl-IV(OCOCH3)(2)(chpda)] (monoclinic P2(1)/a, a = 7.947(1), b = 22.753(11), and c = 10.581(3) Angstrom, beta = 110.70(2)degrees, V = 1790(1) Angstrom(3), Z = 4, R = 0.0534) shows that the platinum(IV) center adopts a typical octahedral arrangement with two acetate groups in a trans position. The pattern and strength of the intramolecular hydrogen bonds are delicately different from those of JM216. Both in vitro and in vivo (oral) cytotoxicities on mouse leukemia L1210 cell line indicate that the activity of chpda chelate analogue is not better than that of the corresponding compound with two monodentate amines (JM216). (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2003.08.006