trans-[(NH3)2Pt(1-methyluracil-N3)Cl] | 1132766-05-2

• 英文名称: trans-[(NH3)2Pt(1-methyluracil-N3)Cl]
• CAS: 1132766-05-2；1130444-38-0；1132766-06-3；85715-78-2；1130444-41-5；220760-69-0
• 化学式: C₅H₁₁ClN₄O₂Pt
• 分子量: 389.701
• InChiKey: XKKVZZMUFXWTHN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  trans-[(NH3)2Pt(1-methyluracil-N3)Cl] 在 水 作用下， 以 水 为溶剂， 生成 cis-[Pt(NH3)2(H2O)(1-methyluracilate-N3)](1+)
  参考文献：
  名称：

  Schmülling, Michael; Lippert, Bernhard; Van Eldik, Rudi, Inorganic Chemistry, 1994, vol. 33, # 15, p. 3276 - 3280

  摘要：

  DOI：

文献信息

• Combining four different model nucleobases (uracil, adenine, guanine, cytosine) via metal binding and H bond formation in a single compound
  作者：Roland K. O. Sigel、Susan M. Thompson、Eva Freisinger、Bernhard Lippert

  DOI：10.1039/a807322h

  日期：——

  A cyclic arrangement of the four model nucleobases 1-methyluracilate (mura), 9-ethyladenine (eade), 9-ethylguanine (Hegua) and 1-methylcytosine (mcyt), held together by two metal entities [trans-(NH3)2PtII and trans-(MeNH2)2PtII] and multiple H bond interactions, is presented.

  呈现了一种四种模型核苷酸基（1-甲基尿嘧啶酸盐（mura）、9-乙基腺嘌呤（eade）、9-乙基鸟嘌呤（Hegua）和1-甲基胞嘧啶（mcyt））的循环排列，这些基团通过两个金属实体 [trans-(NH3)2PtII 和 trans-(MeNH2)2PtII] 和多个氢键相互作用结合在一起。
• Crystal structures of a protonated form of trans-[Pt(NH3)2(mura)2] and of a derivative containing three different metal ions, Pt2+, Ag+, and Na+ (mura = 1-methyluracilate). Major difference in packing between heteronuclear pyrimidine nucleobase complexes of cis- and trans-(NH3)2PtII
  作者：Felix Zamora、Holger Witkowski、Eva Freisinger、Jens Müller、Birgit Thormann、Alberto Albinati、Bernhard Lippert

  DOI：10.1039/a804813d

  日期：——

  complex trans-[Pt(NH3)2(mura)2] 1 (mura = 1-methyluracilate), a compound of very low water solubility, is markedly solubilised in the presence of acid or suitable metal salts due to protonation and metal binding to the exocyclic oxygen atoms, respectively. The perchlorate salt trans-[Pt(NH3)2(Hmura)2][ClO4]2·2H2O 2 has been characterised by X-ray analysis. With Ag+, 1 formed heteronuclear species of varying

  复杂的反式- [PT（NH 3）2（波纹）2 ] -1（波纹= 1-methyluracilate），非常低的水溶解度的化合物，显着地溶解在适当的质子化作用和金属酸或合适的金属盐的存在分别与环外氧原子结合。通过X射线分析对高氯酸盐的反式-[PT（NH 3）2（Hmura）2 ] [ClO 4 ] 2 ·2H 2 O 2进行了表征。与Ag +一起，1形成了不同化学计量比的异核物种，例如PT 2 Ag 3如图3所示，其组成可以通过碱金属盐的存在而进一步改变。复杂的反式- [的PT（NH 3）2（波纹）2 } 2 AGNA（H 2 O）4 ] [CLO 4 ] 2 ·6.5H 2点O 4似乎是第一结构上的特征的核碱基复杂含有例如三种不同的金属离子。的4四核的阳离子被布置成这样的方式在晶体中，以允许NH二者之间的分子间氢键键合3个配体和O 2村核碱基的位点和相邻之间π堆叠反-[PT（NH 3）2（mura）2
• Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes
  作者：Roland K.O Sigel、Eva Freisinger、Michele Abbate、Bernhard Lippert

  DOI：10.1016/s0020-1693(02)00962-3

  日期：2002.11

  Methylation at the N7 position is one of the most frequently naturally occurring modifications of guanosine. This alteration drastically changes the hydrogen bonding and acid-base properties of the guanine nucleobase. Here we show on the example of the model nucleobase 7,9-dimethyl guanine that due to blockage of N7 of the purine ring, new hydrogen bonding patterns occur on the minor groove binding face of this nucleobase involving the ring nitrogen N3 and the exocyclic amino group N2H(2). The free 7,9-dimethylguaninium ion and several transplatinum(II) complexes of the this ligand are presented and discussed. (C) 2002 Elsevier Science B.V. All rights reserved.