[Pd(Me2NCS2)Cl]n | 131996-30-0

• 英文名称: [Pd(Me2NCS2)Cl]n
• CAS: 131996-30-0
• 化学式: C₃H₆ClNPdS₂
• 分子量: 262.092
• InChiKey: WNAWVEUDRIUSGM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.62
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  吡啶 、 [Pd(Me2NCS2)Cl]n 以 二氯甲烷 为溶剂， 以80%的产率得到Pd(Me2NCS2)(pyridine)Cl
  参考文献：
  名称：

  Palladium and platinum dithiocarbamato complexes containing mono- and diamines

  摘要：

  The [M(DMDT)X](n) (M=Pd or Pt; DMDT=Me2NCS2-; X=Cl or Br) species have been reacted with various amines (Py, pyridine; Pra, n-propylamine; Cba, cyclobutylamine; Dap, 1,3-diaminopropane; En, ethylenediamine) in dichloromethane with the aim of obtaining mixed complexes of various stoichiometries. Along with the neutral complexes M(DMDT)(L)X (L=Py, Pra or Cba), the ionic species IM(DMDT)(L,)IX, [M(DMDT)(En)]X and [M(DMDT)(Dap)]X have been isolated, which have been characterised by IR and proton NMR spectroscopy. Thermogravimetric data suggest a particular behaviour for the palladium-Pra and palladium-Cba derivatives, with formation of low-stoichiometry intermediates of formula Pd-2(DMDT)(2)AmX2. The behaviour of the prepared complexes in various solvents has been described on the basis of the proton NMR spectra. All complexes have been tested for in vitro cytostatic activity against KB cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(99)00197-7

文献信息

• Thermal S-demethylation in palladium(II) and platinum(II) complexes with S-methyl N,N-dialkyldithiocarbamates
  作者：G. Faraglia、L. Sindellari、S. Sitran

  DOI：10.1016/0040-6031(90)80287-9

  日期：1990.4

  Pd or Pt; X = Cl or Br) and [Pd(MeS 2 CNEt 2 )Cl 2 ] has been examined up to 1100° C. The first decomposition step involves MeX release to form the corresponding species [M(S 2 CNMe 2 )X] n and [Pd(S 2 CNEt 2 )Cl] n . The degradation intermediates have been isolated and characterized by elemental analyses and IR and NMR ( 1 H and 13 C) spectra. Their possible structure is discussed and correlated with

  摘要 二硫代氨基甲酸酯配合物 [M(MeS 2 CNMe 2 )X 2 ] (M = Pd 或 Pt; X = Cl 或 Br) 和 [Pd(MeS 2 CNEt 2 )Cl 2 ] 的热行为已被研究到1100°C。第一个分解步骤包括释放 MeX 以形成相应的物质 [M(S 2 CNMe 2 )X] n 和 [Pd(S 2 CNEt 2 )Cl] n 。降解中间体已被分离并通过元素分析和 IR 和 NMR（ 1 H 和 13 C）光谱表征。讨论了它们可能的结构并将其与起始二硫代氨基甲酸酯加合物的性质相关联。在加热时，混合络合物 [Pt(S 2 CNEt 2 )(MeS 2 CNR 2 )Cl]（R = Me 或 Et）经历类似的 S-去甲基化过程，MeCl 在低于相同过程的温度下析出[Pt(MeS 2 CNMe 2 )X 2 ] 物种。
• The behaviour of dithiocarbamic ester palladium(II) and platinum(II) complexes in dimethyl sulfoxide
  作者：Giuseppina Faraglia、Sergio Sitran

  DOI：10.1016/s0020-1693(00)85093-8

  日期：1990.10

  planar mixed complexes contain S-bound dimethyl sulfoxide, the platinum derivatives are stabler than the palladium analogues, which release easily the Me 2 SO molecule either on heating or in solution to form the [Pd(S 2 CNMe 2 )X] n species. Accordingly Me 2 SO interaction with the [M(MeS 2 CNMe 2 )X 2 ] complexes depends on the different solvent to metal donor ability. The nature of the interaction

  摘要配合物[M（MeS 2 CNMe 2）X 2]（M = Pd或Pt； X = Cl或Br）在二甲亚砜中分解，生成含有二甲基二硫代氨基甲酸酯部分的物质。为了阐明降解途径，已经制备了混合物质[M（S 2 CNMe 2）（Me 2 SO）X]，并通过红外和1 H NMR光谱以及热分析（TG，DTG和DTA）对其进行了表征。尽管所有方形平面混合配合物均包含S键合的二甲基亚砜，但铂衍生物比钯类似物更稳定，后者在加热或溶液中均可轻松释放Me 2 SO分子以形成[Pd（S 2 CNMe 2）X]。 n种。因此，Me 2 SO与[M（MeS 2 CNMe 2）X 2]配合物的相互作用取决于不同的溶剂对金属供体的能力。
• Pyrrolidine dithiocarbamates of Pd(II)
  作者：Giuseppina Faraglia、Sergio Sitran、Diego Montagner

  DOI：10.1016/j.ica.2004.09.063

  日期：2005.3

  The dithioester (CH2)(4)NCS2CH3 (PyDTM, 1-pyrrolidinecarbodithioate methyl ester) has been prepared by reaction of the parent ammonium salt NH4PyDT (PyDT = (CH2)(4)NCS2-) with methyl iodide in water/ethanol. The reaction of PyDTM with PdCl2 allowed to synthesize either [PdCl2(PyDTM)], in which the ligand is chelated by both sulfur atoms, or [PdCl2(PyDTM)(2)], in which the ligand acts as monodentate through the thiocarbonyl sulfur. Thermal degradation of [PdCl2(PyDTM)] yielded the [PdCl(PyDT)](n) species as an intermediate, which, in the presence of donors as chloride ions or dimethyl sulfoxide (DMSO), gave the complexes [PdCl(PyDT)(DMSO)] and NR4[PdCl2(PyDT)]. Moreover, PyDTM was found to react with various [PdCl(dithiocarbamato)], intermediates to form the mixed species [PdCl(dithiocarbamato)(PyDTM)], whose thermal degradation yielded the [Pd(dithiocarbamato)(PyDT)] complexes. The behaviour of the prepared compounds in either solution or solid phase has been described on the basis of IR and proton NMR spectra and thermogravimetric analysis (TG and DTA). (c) 2004 Elsevier B.V. All rights reserved.
• Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with α,ω-diamines
  作者：Diego Montagner、Cristina Marzano、Valentina Gandin

  DOI：10.1016/j.ica.2011.07.031

  日期：2011.10

  The polymeric [PdCl(dithiocarbamate)](n) complexes, in which the ligand ion is dimethyldithiocarbamate (DMDT), pyrrolidine dithiocarbamate (PyDT, (CH2)(4)NCS2-) and sarcosine ethyl ester dithiocarbamate (ESDT, EtO2CCH2N(CH3)CS2-), have been reacted with chelating diamines, like ethylenediamine (en) or 1,3-diaminopropane (dap) and long chain diamines, like 1,4-diaminobutane (dab) or 1,7-diaminoheptane (dah). The reaction products depend on either diamine chain length or molar ratio. By operating at PdCl(dithiocarbamate)/diamine molar ratio 1:1 chelating diamines yielded the ionic [Pd(dithiocarbamate)(diamine)]Cl species (diamine = en or dap), whereas with long chain diamines species of the type [Pd(dithiocarbamate)(diamine)](n)Cl-n (diamine = dab or dah) were obtained, in which each Pd(dithiocarbamate)(+) unit binds to the NH2 group of two different molecules, in a network of bridging diamines. At molar ratio 1:0.5, the long chain diamines yielded the binuclear [Pd2Cl2(dithiocarbamate)(2)(diamine)] complexes (diamine = dab or dah), whereas exchange reactions take place generally in the presence of en or dap. The reaction trend is described on the basis of IR and proton NMR spectra. The new dithiocarbamate complexes were preliminarily tested for their cytotoxicity on human cancer cells. (C) 2011 Elsevier B.V. All rights reserved.