[Sn2Cl7(1,2-bis(1H-benzimidazol-2-yl)-1,2-ethanediol(-1H))] | 958870-65-0

• 英文名称: [Sn2Cl7(1,2-bis(1H-benzimidazol-2-yl)-1,2-ethanediol(-1H))]
• CAS: 958870-65-0
• 化学式: C₁₆H₁₃Cl₇N₄O₂Sn₂
• 分子量: 778.896
• InChiKey: PYZOQVIOPZGBFS-FLYCNLMGSA-G

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Sn2Cl7(1,2-bis(1H-benzimidazol-2-yl)-1,2-ethanediol(-1H))] 、 1,8-dihydro-1,3,6,8,10,13-hexaazacyclotetradecane-copper(II) perchlorate 在 sodium hydroxide 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 以60%的产率得到
  参考文献：
  名称：

  Stannoxane capping derived from chiral tridentate NNO donor ligand for nickel and copper macrocycles: Comparative binding studies of stannoxane moiety and its modulated copper complex with CTDNA

  摘要：

  Novel stannoxane type dinuclear tin complex C16H13N4O2Sn2Cl7 (1) and its modulated macrocyclic complexes [C24H36N10O3Sn2CUCl7] ClO4 (2) and [C24H34N10O2Sn2NiCl7) ClO4 (3) were synthesized and characterized by elemental analysis and various spectroscopic techniques (1R, H-1, C-13, Sn-119 NMR, ESI-MS, EPR and UV-Vis). Sn-119 NMR shows the presence of two tin metal centers in different environment. The proposed pseudo-octahedral geometry of copper in complex 2 and square pyramidal geometry of nickel in complex 3 were established by the analysis of spectroscopic data. Absorption and fluorescence spectral studies and viscosity measurements have been carried out to assess the comparative binding of dinuclear stannoxane complex 1 and its modulated copper complex 2 with calf thymus DNA. The intrinsic binding constants K-b of the complex 1 and 2 were determined as 4.4 x 10(4) M-1 and 7.5 x 10(4) M-1, respectively. Cyclic voltammetric studies have also been employed to ascertain the binding of complex 2 with CTDNA. The results suggest that the complex 2 binds to CTDNA twice in the order of magnitude compared to complex 1. Interaction studies of complex 2 with guanosine 5'-monophosphate further confirm the binding via N-7 position of guanine and phosphate moiety. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2007.07.044
• 作为产物：
  描述：

  1,2-双(1H-苯并咪唑-2-基)乙烷-1,2-二醇 、 四氯化锡 以 甲醇 、 四氯化碳 为溶剂， 以62%的产率得到[Sn2Cl7(1,2-bis(1H-benzimidazol-2-yl)-1,2-ethanediol(-1H))]
  参考文献：
  名称：

  Stannoxane capping derived from chiral tridentate NNO donor ligand for nickel and copper macrocycles: Comparative binding studies of stannoxane moiety and its modulated copper complex with CTDNA

  摘要：

  Novel stannoxane type dinuclear tin complex C16H13N4O2Sn2Cl7 (1) and its modulated macrocyclic complexes [C24H36N10O3Sn2CUCl7] ClO4 (2) and [C24H34N10O2Sn2NiCl7) ClO4 (3) were synthesized and characterized by elemental analysis and various spectroscopic techniques (1R, H-1, C-13, Sn-119 NMR, ESI-MS, EPR and UV-Vis). Sn-119 NMR shows the presence of two tin metal centers in different environment. The proposed pseudo-octahedral geometry of copper in complex 2 and square pyramidal geometry of nickel in complex 3 were established by the analysis of spectroscopic data. Absorption and fluorescence spectral studies and viscosity measurements have been carried out to assess the comparative binding of dinuclear stannoxane complex 1 and its modulated copper complex 2 with calf thymus DNA. The intrinsic binding constants K-b of the complex 1 and 2 were determined as 4.4 x 10(4) M-1 and 7.5 x 10(4) M-1, respectively. Cyclic voltammetric studies have also been employed to ascertain the binding of complex 2 with CTDNA. The results suggest that the complex 2 binds to CTDNA twice in the order of magnitude compared to complex 1. Interaction studies of complex 2 with guanosine 5'-monophosphate further confirm the binding via N-7 position of guanine and phosphate moiety. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2007.07.044