| 1384168-22-2

• CAS: 1384168-22-2
• 化学式: C₂₃H₁₇Cl₃N₂Pd
• 分子量: 534.18
• InChiKey: SRTRBVIRVLWBDO-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  sodium tetrachloropalladate(II) 、 6-(4-chlorophenyl)-4-p-tolyl-2,2'-bipyridine 在 HCl 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Interaction of palladium(II) coordination compounds with calf thymus DNA and their antibacterial activity

  摘要：

  The palladium(II) complexes of the formulations [Pd(clpbpy)Cl-2], [Pd(clcpbpy)Cl-2], [Pd(brcpbpy)Cl-2], [Pd(clmpbpy)Cl-2] {clpbpy=4-(4-chlorophenyl)-6-phenyl-2,2'-bipyridine (L-1), clcpbpy=4,6-bis(4-chlorophenyl)-2,2'-bipyridine (L-2), brcpbpy=4-(4-bromophenyl)-6-(4-chlorophenyl)-2,2'-bipyridine (L-3) and clmpbpy=6-(4-chlorophenyl)-4-p-tolyl-2,2'-bipyridine (L-4)} have been synthesized and characterized using elemental analysis, electronic spectra. IR and mass spectra. The study on the interaction of the palladium complexes with calf thymus DNA (CT DNA) has been performed using absorption titration, viscosity measurements and thermal denaturation techniques. The study suggests the intercalative mode of DNA binding. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the pUC19 DNA. The antibacterial activity of complexes has been screened against two Gram((+ve)) and three Gram((-ve)) microorganisms. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2012.04.011