1-(3-ethoxyphenyl)-N-methylmethanimine | 16928-31-7

• 英文名称: 1-(3-ethoxyphenyl)-N-methylmethanimine
• 英文别名: (3-ethoxy-benzylidene)-methyl-amine；(3-Aethoxy-benzyliden)-methyl-amin
• CAS: 16928-31-7
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: PYWDPLYTZSBSCE-UHFFFAOYSA-N

物化性质

• 沸点：
  122 °C(Press: 12 Torr)
• 密度：
  0.93±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-ethoxyphenyl)-N-methylmethanimine 在 sodium tetrahydroborate 作用下， 以 甲醇 、 水 为溶剂， 反应 2.5h， 生成 (3-乙氧基苯基)-N-甲基甲胺
  参考文献：
  名称：

  4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

  摘要：

  Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.050
• 作为产物：
  描述：

  3-乙氧基苯甲醛 、 甲胺 以 甲醇 、 水 为溶剂， 反应 0.33h， 生成 1-(3-ethoxyphenyl)-N-methylmethanimine
  参考文献：
  名称：

  4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

  摘要：

  Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.050

文献信息

• Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron
  作者：Mingkang Zhou、Kaidi Li、Dongping Chen、Ronghua Xu、Guangqing Xu、Wenjun Tang

  DOI：10.1021/jacs.0c04558

  日期：2020.6.10

  We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method

  我们在此报告了一种通用、实用且高效的方法，通过手性二硼模板化的亚胺的还原偶联不对称合成各种手性邻二胺。该协议具有高对映选择性和立体特异性、温和的反应条件、简单的操作程序、使用现成的起始材料和广泛的底物范围。该方法表明了启用二硼的 [3,3]-σ 重排的普遍性。
• Analgesics. II.¹ The Grignard Reaction with Schiff Bases²
  作者：Robert Bruce Moffett、Willard M. Hoehn

  DOI：10.1021/ja01199a061

  日期：1947.7