| 915728-38-0

• CAS: 915728-38-0
• 化学式: C₂₃H₂₂Cl₃NOPtS
• 分子量: 661.939
• InChiKey: ZAXNCBQSECFPLP-KRHPGHLWSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  (2,6-Cl2C6H3)CH=NCH2(4'-ClC6H4) 在 Na₂(CH₃CO₂)2 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Unprecedented intermolecular C–H bond activation of a solvent toluene molecule leading to a seven-membered platinacycle

  摘要：

  报告中介绍了一种新型的铂介导过程，包括甲苯的一个 CarylâH 键的分子间活化、一个亚胺 CarylâCl 键的分子内活化以及一个 CâC 键的形成。

  DOI：

  10.1039/b608666g

文献信息

• A comparative study of the structures and reactivity of cyclometallated platinum compounds of N-benzylidenebenzylamines and cycloplatination of a primary amine
  作者：Alejandro Capapé、Margarita Crespo、Jaume Granell、Mercè Font-Bardía、Xavier Solans

  DOI：10.1039/b618128g

  日期：——

  The reaction of cis-[PtCl2(dmso)2] with ligands 4-ClC6H4CHNCH2C6H5 (1a) and 4-ClC6H4CHNCH2(4-ClC6H4) (1b) in the presence of sodium acetate and using either methanol or toluene as solvent produced the corresponding five-membered endo-metallacycles [PtCl(4-ClC6H3)CHNCH2C6H5}SOMe2}] (2a) and [PtCl(4-ClC6H3)CHNCH2(4′-ClC6H4)}SOMe2}] (2b). An analogous reaction for ligands 2,6-Cl2C6H3CHNCH2C6H5 (1c) and 2,6-Cl2C6H3CHNCH2(4-ClC6H4) (1d) produced five-membered exo-metallacycles [PtCl(2,6-Cl2C6H3)CHNCH2C6H4}SOMe2}] (2c) and [PtCl(2,6-Cl2C6H3)CHNCH2(4′-ClC6H3)}SOMe2}] (2d) when the reaction was carried out in methanol and seven-membered endo-platinacycles [PtCl(MeC6H3)ClC6H3CHNCH2C6H4}SOMe2}] (3c) and [PtCl(MeC6H3)ClC6H3CHNCH2(4′-ClC6H3)}SOMe2}] (3d) when toluene was used as a solvent. The reaction of 2,4,6-(CH3)3C6H2CHNCH2(4-ClC6H4) (1e) produced in both solvents an exo-platinacycle [PtCl(2,4,6-(CH3)3C6H2)CHNCH2(4′-ClC6H3)}SO(CH3)2}] (2e). Cyclometallation of 4-chlorobenzylamine was also achieved to produce compound [PtCl(4-ClC6H3)CH2NH2}SOMe2}] (2g). The reactions of endo- and exo-metallacycles with phosphines evidenced the higher lability of the Pt–N bond in exo-metallacycles while a comparative analysis of the crystal structures points out a certain degree of aromaticity in the endo-metallacycle.

  6-CH3)3C6H2CHNCH2(4-ClC6H4)}SOMe2}] (2e)和[PtCl(2,4,6- )3C6H2CHNCH2(4′-ClC6H3)}Scis-[PtCl2(dmso)2]与配体4-ClC6H4CHNCH2C6H5 (1a)和4-ClC6H4CHNCH2(4-ClC6H4) (1b)在乙酸钠存在下发生反应，使用甲醇或甲苯作为溶剂，生成相应的五元内型金属环[PtCl(4-ClC6H3)CHNCH2C6H5}SOMe2}] (2a)和[PtCl(4-ClC6H3)CHNCH2(4′-ClC6H4)}SOMe2}] (2b)。配体2,6-Cl2C6H3CHNCH2C6H5 (1c)和2,6-Cl2C6H3CHNCH2(4-ClC6H4) (1d)发生类似反应，在甲醇中反应生成五元外型金属环[PtCl(2,6-Cl2C6H3)CHNCH
• Platinum-Mediated C−H Bond Activation of Arene Solvents and Subsequent C−C Bond Formation
  作者：Joan Albert、Ramon Bosque、Margarita Crespo、Jaume Granell、Judit Rodríguez、Javier Zafrilla

  DOI：10.1021/om100743z

  日期：2010.10.25

  The reactions of cis-[PtCl2(SOMe2)(2)] and imines 2,6-Cl2C6H3CH=NCH2(4-XC6H4) (1a, X = H; 1b, X = Cl), 2,6-Cl2C6H3CH=NCH2(2,6-F2C6H3) (1f), and 2,6-Cl2C6H3CH=N(4-ClC6H4) (1g) carried out in toluene at 90 degrees C in the presence of sodium acetate dissolved in methanol produced compounds [PtCl(MeC6H3)(2-ClC6H3)CHNR)}SOMe2] (R = CH2C6H5 (4a), CH2(4-ClC6H4) (4b), CH2(2,6-F2C6H3) (4f), and 4-ClC6H4 (4g)), containing seven-membered platinacycles via "formal insertion" of a toluene molecule in the metallacycle. These compounds are formed in a process involving several steps, the most relevant being intermolecular C-H activation of a solvent toluene molecule and formation of a carbon-carbon bond. The reaction of cis-[PtCl2(SOMe2)(2)] and imine 2,6-Cl2C6H3CH=NCH2(4-CIC6H4) (1b) under analogous conditions was also carried out using other arene solvents such as benzene and ortho-, meta-, and para-xylene and produced in all cases seven-membered platinacycles. DFT calculations indicate that the stability of the metallacycles increases in the order p-xylyl < m-xylyl < o-xylyl < tolyl < phenyl and have helped to suggest a possible reaction path.