[Cu([(6-methyl-2-pyridylmethyl)-bis(2-pyridylmethyl)]amine)Cl]ClO₄ | 182913-19-5

• 英文名称: [Cu([(6-methyl-2-pyridylmethyl)-bis(2-pyridylmethyl)]amine)Cl]ClO₄
• 英文别名: [CuCl(((6-methyl-2-pyridyl)methyl)bis(2-pyridylmethyl)amine)]ClO4
• CAS: 182913-19-5
• 化学式: C₁₉H₂₀ClCuN₄*ClO₄
• 分子量: 502.844
• InChiKey: OKHMFZCELMIFLZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  6-甲基-2-吡啶基甲醇 在 磺酰氯 作用下， 以 甲醇 、 四氯化碳 为溶剂， 反应 0.08h， 生成 [Cu([(6-methyl-2-pyridylmethyl)-bis(2-pyridylmethyl)]amine)Cl]ClO₄
  参考文献：
  名称：

  基于三脚架吡啶胺衍生物的 铜（ii）配合物作为有效的抗癌药†

  摘要：

  的配合物[铜（TPA）CL] CLO 4 ·½H 2 O（1-CLO 4），[Cu（上6- MeTPA）CL] CLO 4 / PF 6（ 2-CLO 4 / 2-PF 6），[铜（6-Me 2 TPA）Cl] PF 6（3-PF 6），[Cu（BPQA）Cl] ClO 4 / PF 6（4-ClO 4 / 4-PF 6），[Cu（BPQA）Cl] ClO 4 / PF 6（4-ClO 4 / 4-PF 6），[Cu（BQPA）Cl] ClO 4 / PF 6（5-ClO 4 / PF 6），[Cu（L 1）Cl] ClO 4 / PF 6（6-ClO 4 / 6-PF 6），[Cu（L 2）Cl] ClO 4（7-ClO 4）合成了[Cu（L 3）Cl] ClO 4（8-ClO 4），并通过光谱技术和单X射线晶体学对其结构进行了表征。在体外的细胞毒性所制备的铜（II）针对A2780（卵巢

  DOI：

  10.1039/c9nj00061e

文献信息

• Structural and Electrochemical Comparison of Copper(II) Complexes with Tripodal Ligands
  作者：Hirotaka Nagao、Nobutoshi Komeda、Masao Mukaida、Masatatsu Suzuki、Koji Tanaka

  DOI：10.1021/ic960303n

  日期：1996.1.1

  A series of copper(II) complexes with tripodal polypyridylmethylamine ligands, such as tris(2-pyridylmethyl)amine (tpa), ((6-methyl-2-pyridyl)methyl)bis(2-pyridylmethyl)amine (Me(1)tpa), bis((6-methyl-2-pyridyl)methyl)(2-pyridylmethyl)amine (Me(2)tpa), and tris((6-methyl-2-pyridyl)methyl)amine (Me(3)tpa), have been synthesized and characterized by X-ray crystallography. [Cu(H2O)(tpa)](ClO4)(2) (1) crystallized in the monoclinic system, space group P2(1)/a, with a = 15.029(7) Angstrom, b = 9.268(2) Angstrom, c = 17.948(5) Angstrom, beta = 113.80(3)degrees and Z = 4 (R = 0.061, R(w) = 0.059). [CuCl(Me(1)tpa)]ClO4 (2) crystallized in the triclinic system, space group , with a = 13.617(4) Angstrom, b = 14.532(4) Angstrom, c = 12.357(4) Angstrom, alpha = 106.01(3)degrees, beta = 111.96(2)degrees, gamma = 71.61(2)degrees, and Z = 4 (R = 0.054, R(w) = 0.037). [CuCl(Me(2)tpa)]ClO4 (3) crystallized in the monoclinic system, space group P2(1)/n, with a = 19.650(4) Angstrom, b = 13.528(4) Angstrom, c = 8.55(1) Angstrom, beta = 101.51(5)degrees and Z = 4 (R = 0.071, R(w) = 0.050). [CuCl(Me(3)tpa)][CuCl2(Me(3)tpa)]ClO4 (4) crystallized in the monoclinic system, space group P2(1)/a, with a = 15.698(6) Angstrom, b = 14.687(7) Angstrom, c = 19.475(4) Angstrom, beta = 97.13(2)degrees, and Z = 4 (R = 0.054, R(w) = 0.038). All the Cu atoms of 1-4 have pentacoordinate geometries with three pyridyl and one tertiary amino nitrogen atoms, and a chloride or aqua oxygen atom. Nitrite ion coordinated to the Cu(II) center of Me(1)tpa, Me(2)tpa, and Me(3)tpa complexes with only oxygen atom to form nitrito adducts. The cyclic voltammograms of [Cu(H2O)(Me(n)tpa)](2+) (n = 0, 1, 2, and 3) in the presence of NO2- in H2O (pH 7.0) revealed that the catalytic activity for the reduction of NO2- increases in the order Me(3)tpa << Me(2)tpa << Me(1)tpa < tpa complexes.