1-{p-(alpha-bromo)tolyl}-1,2-dicarba-closo-dodecaborane | 150174-85-9

• 英文名称: 1-{p-(alpha-bromo)tolyl}-1,2-dicarba-closo-dodecaborane
• 英文别名: p-(o-carboran-1-yl)benzyl bromide
• CAS: 150174-85-9
• 化学式: C₉H₁₇B₁₀Br
• 分子量: 313.248
• InChiKey: HPCYIZQUYXCMKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-{p-(alpha-bromo)tolyl}-1,2-dicarba-closo-dodecaborane 、 甲酰氨基丙二酸二乙酯 在 sodium 、 sodium iodide 作用下， 以 乙醇 为溶剂， 以87%的产率得到diethyl p-{1,2-dicarba-closo-dodecaboran(12)-1-yl}benzyl(formamido)malonate
  参考文献：
  名称：

  Prashar, Jognandan K.; Moore, Douglas E., Journal of the Chemical Society. Perkin transactions I, 1993, # 9, p. 1051 - 1054

  摘要：

  DOI：
• 作为产物：
  描述：

  4-{1,2-dicarba-closo-dodecaboran(12)-1-yl}phenylmethanol 、 三溴化磷 在 吡啶 作用下， 以 苯 为溶剂， 以78%的产率得到1-{p-(alpha-bromo)tolyl}-1,2-dicarba-closo-dodecaborane
  参考文献：
  名称：

  Prashar, Jognandan K.; Moore, Douglas E., Journal of the Chemical Society. Perkin transactions I, 1993, # 9, p. 1051 - 1054

  摘要：

  DOI：

文献信息

• Synthesis of Carboranyl Amino Acids, Hydantoins, and Barbiturates
  作者：Iwona M. Wyzlic、Werner Tjarks、Albert H. Soloway、Douglas J. Perkins、Minerva Burgos、Kevin P. O'Reilly

  DOI：10.1021/ic9511229

  日期：1996.1.1

  The syntheses of three novel boronated hydantoins, 5-(o-carboran-1-ylmethyl)hydantoin, 14, the tetraphenylphosphonium salt of 7-(hydantoin-5-ylmethyl)dodecahydro-7, 8-dicarba-nido-undecaborate, 15, 5-(o-carboran-1-ylmethyl)-2-thiohydantoin, 16, and two new barbiturates, 5,5-bis(but-2-ynyl)barbiturate, 18, and 5,5-bis[(2-methyl-o-carboran-1-yl)methyl]barbiturate, 20, are described. Hydantoins 14-16 were synthesized from o-carboranylalanine (Car, 13). The detailed syntheses of Car and two other carborane-containing amino acids, O-(o-carboran-1-ylmethyl)tyrosine (CBT, 5a) and p-(o-carboran-1-yl)phenylalanine (CBPA, 5b), presented earlier as a communication,(16) are also described. Hydantoin 14 and barbiturates 18 and 20 were tested for their potential anticonvulsant activity. Initial qualitative screening showed moderate activities for hydantoin 14 and barbiturate 18. Barbiturate 20 had no activity. Compound 14 appeared to be nontoxic at doses of 300 mg/kg (mice, ip) and 50 mg/kg (rats, oral). However, 18 was very toxic under similar conditions.