cis-(gly-L-alaOMe)2PtCl2 | 98798-16-4

• 英文名称: cis-(gly-L-alaOMe)2PtCl2
• 英文别名: trans-PtCl2(Gly-L-AlaOMe)2
• CAS: 98798-16-4
• 化学式: C₁₂H₂₄Cl₂N₄O₆Pt
• 分子量: 586.332
• InChiKey: WHVRFOUNEGUZLC-QDILMJESSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  cis-(gly-L-alaOMe)2PtCl2 在 盐酸 、 1,2-双(二苯基膦)乙烷 作用下， 以 乙醇 为溶剂， 生成 {Pt(dppe)2}Cl2
  参考文献：
  名称：

  Beck, Wolfgang; Bissinger, Herbert; Castrillo de Castro, Thais, Chemische Berichte, 1985, vol. 118, p. 3135 - 3142

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(Trimethylsilyl)-L-alanin-methylester 、 trans-Dichlorobis(glycylchlorid)platin (II) 以 二氯甲烷 为溶剂， 以95%的产率得到cis-(gly-L-alaOMe)2PtCl2
  参考文献：
  名称：

  Steiner, Norbert; Ehrensdorfer, Eva; Chen, Jingtang, Chemische Berichte, 1988, vol. 121, p. 275 - 280

  摘要：

  DOI：

文献信息

• Binary and ternary complexes of platinum(II) with the dipeptide esters gly-glyOEt, gly-alaOMe, gly-2-abaOMe, gly-nvalOMe, gly-nleuOMe, and the nucleosides guo (guanosine) and cyd (cytidine)
  作者：E. Katsarou、A. Troganis、N. Hadjiliadis

  DOI：10.1016/s0020-1693(96)05409-6

  日期：1997.3

  The binary complexes of formulae cis-(dipeptide)(2)PtCl2 and the ternary complexes of formulae cis-[(guo)(2)Pt(dipeptide)(2)]Cl-2 and cis[(cyd)(2) Pt(dipeptide)(2)]Cl-2, with guo = guanosine, cyd = cytidine, dipeptide = glyglyOEt, gly-1-alaOMe, gly-2-1-abaOMe, gly-1-nvalOMe, gly-1-nleuOMe, were isolated and characterized by elemental analysis, conductivity measurements, H-1, C-13 NMR and IR spectroscopy. The binary complexes were obtained by the reaction of K2PtCl4 with the dipeptide esters and the ternary ones by further reactions of the binary complexes with the corresponding nucleosides. The dipeptides are monocoordinated through their amino groups with Pt2+. Ligand-ligand hydrophobic interactions were observed to decrease with distance from the bonding sites. The percentages of the E-3 and anti conformations of the nucleosides increase, while the gg ones decrease in the complexes. Finally, the h conformers around the -CH alpha-CH beta R- bonds of the peptides decrease on passing to the ternary from the binary system and increase with longer aliphatic chains.