1-chloro-1-(pyridin-1-ium-1-yl)ethan-1-ide | 122567-46-8

• 英文名称: 1-chloro-1-(pyridin-1-ium-1-yl)ethan-1-ide
• CAS: 122567-46-8
• 化学式: C₇H₈ClN
• 分子量: 141.6
• InChiKey: VSUZIKWENFCQED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  吡啶 、 1-exo-methyl-1-endo-chloro-1a,9b-dihydrocyclopropaphenanthrene 以 异辛烷 为溶剂， 反应 0.83h， 生成 1-chloro-1-(pyridin-1-ium-1-yl)ethan-1-ide
  参考文献：
  名称：

  Laser Flash Photolysis Study of Alkylhalocarbenes Generated from Non-Nitrogenous Precursors

  摘要：

  Previously we have studied the photochemistry of alkylchlorodiazirines using laser flash photolysis methods and the pyridine ylide technique (White et al. J. Org. Chem. 1992, 17, 2841). The yield of trappable carbene was found to be a sensitive function of the alkylcarbene structure. This was attributed to ring opening of the diazirine to form a biradical which could suffer rearrangement, in addition to fragmentation to a carbene. It was also possible to explain the data in terms of a carbene-pyridine complex which can either rearrange or collapse to an ylide. In this work, alkylchlorocarbenes are generated from phenanthridenes. The results do not rule out the intermediacy of a carbene-pyridine complex; however, if this species is formed, it does not rearrange to chloroalkene in competition with collapse to form an ylide. This study reduces the urgency with which to postulate carbene-olefin complexes (Tomioka et al. J. Am. Chem. Soc. 1984, 106, 454).

  DOI：

  10.1021/jp972464y

文献信息

• The thermodynamics of the formation of pyridinium ylides from carbienes
  作者：Joseph A. LaVilla、Joshua L. Goodman

  DOI：10.1016/s0040-4039(00)97044-8

  日期：——

  for the two carbenes and can be related to the pKa's of the pyridines. Steric interactions between the carbenes and several substituted prydines result in an apparent decrease in the reaction enthalpy from that predicted by the pyridenes pKa's.

  通过光声量热法测定甲基和苯基氯卡宾与取代的吡啶络合的反应焓。焓是两个卡宾相似，可与的pK一个S中的吡啶的”。的卡宾和几个取代prydines之间的空间相互作用导致在反应焓与由pyridenes的pK预测的明显减少一的。
• PROCESS FOR THE PURIFICATION OF ESLICARBAZEPINE ACETATE
  申请人：Koilpillai Joseph Prabahar

  公开号：US20120022047A1

  公开（公告）日：2012-01-26

  The present invention relates to the purification and particle size of eslicarbazepine acetate. The present invention also relates to the physical characteristics of solid state eslicarbazepine acetate, and pharmaceutical compositions containing the same.

  本发明涉及艾司卡巴酮乙酸酯的纯化和粒径。本发明还涉及固态艾司卡巴酮乙酸酯的物理特性以及含有该物质的制药组合物。
• Methylchlorocarbene: measurement of rate constants for 1,2-hydrogen migration and addition to alkenes
  作者：Michael T. H. Liu、Roland Bonneau

  DOI：10.1021/ja00199a075

  日期：1989.8
• A PROCESS FOR THE PURIFICATION OF ESLICARBAZEPINE ACETATE
  申请人：Glenmark Generics Limited

  公开号：EP2414335A2

  公开（公告）日：2012-02-08
• [EN] A PROCESS FOR THE PURIFICATION OF ESLICARBAZEPINE ACETATE<br/>[FR] PROCÉDÉ DE PURIFICATION DE L'ACÉTATE D'ESLICARBAZÉPINE
  申请人：GLENMARK GENERICS LTD

  公开号：WO2010113179A2

  公开（公告）日：2010-10-07

  A process for purifying eslicarbazepine acetate is provided The crystalline particles of eslicarbazepine acetate having a median particle size between 5 μm and 20 μm and a specific surface area of from 0.1 m2/g to 10 m2/g as measured by B.E.T. method are obtained Eslicarbazepine acetate having purity greater than 99.0% as measured by high performance liquid chromatography and a pharmaceutical composition containing the same are also provided.