[Ru(2,2′;6′,2″-terpyridine)(1,10-phenanthroline)Cl]Cl | 148660-33-7

• 英文名称: [Ru(2,2′;6′,2″-terpyridine)(1,10-phenanthroline)Cl]Cl
• 英文别名: [Ru^II(2,2′:6′,2″-terpyridine)(1,10-phenanthroline)Cl]Cl；[Ru(2,2’:6’,2’’-terpyridine)(1,10-phenantroline)Cl]Cl；[Ru(2,2’:6’,2’’-terpyridine)(1,10-phenanthroline)Cl]；[Ru(tpy)(phen)Cl]Cl；[Ru(tpy)(phen)Cl]；[Ru(2,2':6,2''-terpyridine)(1,10-phenanthroline)Cl]Cl
• CAS: 148660-33-7
• 化学式: C₂₇H₁₉ClN₅Ru*Cl
• 分子量: 585.457
• InChiKey: GKODDRLSXGOCSH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  [Ru(2,2′;6′,2″-terpyridine)(1,10-phenanthroline)Cl]Cl 、 水 生成 [Ru(2,2':6',2''-terpyridine)(1,10-phenantroline)(H2O)](2+)
  参考文献：
  名称：

  立体和电子调节[RuII（terpy）（N ^ N）Cl] Cl配合物的反应性

  摘要：

  摘要[RuII（terpy）（phen）Cl] Cl和[RuII（terpy）（tmen）Cl] ClO4（其中terpy = 2,2'：6'，2''-terpyridine，phen = 1,10的取代行为-苯那曲林，tmen = N，N，N'，N'-四甲基乙二胺）。配合物的晶体结构通过单晶X射线衍射测定。溶液中复合物的结构通过ESI-MS和多核NMR光谱法确认。[RuII（terpy）（phen）Cl] +和[RuII（terpy）（tmen）Cl] +在水溶液中的稳定性，酸度和相应水衍生物在氯化物，硫脲和N，N'-二甲基硫脲中的取代行为，进行了研究。取代反应的动力学是在拟一级反应条件下，使用紫外-可见光谱作为亲核试剂浓度和温度的函数进行的。将tmen和phen配合物的反应性和pKa值与早期研究的Ru（II）聚吡啶配合物进行了比较。所有检查过的Ru（II）配合物的水行为取决于旁观者双齿配体提供的电子和空间特性。

  DOI：

  10.1016/j.ica.2020.119449
• 作为产物：
  描述：

  α,α,α-三联吡啶 在 三乙胺 、 lithium chloride 作用下， 以 乙醇 、 水 为溶剂， 反应 23.0h， 生成 [Ru(2,2′;6′,2″-terpyridine)(1,10-phenanthroline)Cl]Cl
  参考文献：
  名称：

  烟酰胺辅因子的可见光驱动转移与强健的钌配合物光催化剂

  摘要：

  在钌络合物Ru（tpy）（biq）Cl 2（tpy = 2时）下，通过光催化转移氢化，成功实现了烟酰胺辅因子的高效再生，量子产率（Φ）为7.9×10 -3。 2'：6'，2''-吡啶和biq = 2,2'-双喹啉）。该光催化系统不仅高效，而且对氨基酸残基具有耐受性。这种光催化剂与谷氨酸脱氢酶的结合使得L的可控和有效合成成为可能-谷氨酸待实现。已经提出了涉及光诱导的配体交换，脱羧和氢化物转移的机理。动力学同位素实验揭示的脱羧的[Ru（TPY）（BIQ）HCOO] +到的[Ru（TPY）（BIQ）H] +是速率决定步骤与3.2±0.4千卡mol的小表观活化能- 1。通过反应平衡估计[Ru（tpy）（biq）H] +的水合度为40±3 kcal mol -1。

  DOI：

  10.1039/d0gc00331j

文献信息

• Effects of the Bidentate Ligand on the Photophysical Properties, Cellular Uptake, and (Photo)cytotoxicity of Glycoconjugates Based on the [Ru(tpy)(NN)(L)]²⁺ Scaffold
  作者：Lucien N. Lameijer、Tobias G. Brevé、Vincent H. S. van Rixel、Sven H. C. Askes、M. A. Siegler、Sylvestre Bonnet

  DOI：10.1002/chem.201705388

  日期：2018.2.21

  with general formula [Ru(tpy)(N−N)(L)]+/2+ (tpy=2,2′:6′,2′′‐terpyridine, N−N=bpy (2,2′‐bipyridine), phen (1,10‐phenanthroline), dpq (pyrazino[2,3‐f][1,10]phenanthroline), dppz (dipyrido[3,2‐a:2′,3′‐c]phenazine, dppn (benzo[i]dipyrido[3,2‐a:2′,3′‐c]phenazine), pmip (2‐(4‐methylphenyl)‐1H‐imidazo[4,5‐f][1,10]phenanthroline), pymi ((E)‐N‐phenyl‐1‐(pyridin‐2‐yl)methanimine), or azpy (2‐(phenylazo)pyridine)

  聚吡啶钌配合物作为光动力疗法（PDT）和光化疗（PACT）中的潜在化疗药物受到了广泛关注。在这里，我们研究了一系列十六种钌聚吡啶配合物，通式为 [Ru(tpy)(N−N)(L)] +/2+ (tpy=2,2′:6′,2′′-三联吡啶，N -N=bpy (2,2′-联吡啶)、phen (1,10-菲咯啉)、dpq (吡嗪基[2,3- f ][1,10]菲咯啉)、dppz (联吡啶并[3,2- a ]： 2′,3′- c ]吩嗪、dppn（苯并[ i ]二吡啶并[3,2- a :2′,3′- c ]吩嗪）、pmip（2-(4-甲基苯基）-1H-咪唑[ 4,5- f ][1,10]菲咯啉)、pymi(( E ) -N-苯基-1-(吡啶-2-基)甲胺)或azpy(2-(苯基偶氮)吡啶)，L=Cl -或 2-(2-(2-(甲硫基)乙氧基)乙氧基)乙基-β-d-吡喃葡萄糖苷)及其用于 PDT 或 PACT
• Further Observations on Water Oxidation Catalyzed by Mononuclear Ru(II) Complexes
  作者：Nattawut Kaveevivitchai、Ruifa Zong、Huan-Wei Tseng、Raghu Chitta、Randolph P. Thummel

  DOI：10.1021/ic202174j

  日期：2012.3.5

  A family of 28 mononuclear Ru(II) complexes have been prepared and characterized by H-1 NMR, electronic absorption, and cyclic voltammetry. These complexes are studied as catalysts for water oxidation. All the catalysts possess one tridentate ligand, closely related to 2,2';6,2 ''-terpyridine (tpy) and may be divided into two basic types. In the type-1 catalyst, the three remaining coordination sites are occupied by a bidentate closely related to 2,2'-bipyridine (bpy) and a monodentate halogen (Br, Cl, or I) or water molecule. In the type-2 catalyst, the three remaining coordination sites are occupied by two axial 4-picoline molecules and an equatorial halogen or water. In general the type-2 catalysts are more reactive than the type-1. The type-2 iodo-catalyst shows first-order behavior and, unlike the bromo- and chloro-catalysts, does not require water-halogen exchange to show good activity. The importance of steric strain and hindrance around the metal center is examined. The introduction of three t-butyl groups at the 4, 4', and 4 '' positions of tpy sometimes improves catalyst activity, but the effect does not appear to be additive.
• Synthesis, characterization, and anticancer activity of ruthenium(II)-β-carboline complex
  作者：Yu Chen、Meng-Ying Qin、Jing-Heng Wu、Lei Wang、Hui Chao、Liang-Nian Ji、An-Long Xu

  DOI：10.1016/j.ejmech.2013.09.051

  日期：2013.12

  Four [Ru(tpy)(N N)(L)] type complexes: [Ru(tpy)(bpy)(Nh)](2+) (Ru1, tpy = 2,2';6',2 ''-terpyridine, bpy = 2'2-bipyridine, Nh = Norharman), [Ru(tpy)(phen)(Nh)](2+) (Ru2, phen = 1,10-phenanthroline), [Ru(tpy)(dpa)(Nh)](2+) (Ru3, dpa = 2,2'-dipyridylamine) and [Ru(tpy)(dip)(Nh)](2+) (Ru4, dip = 4,7-diphenyl-1,10-phenanthroline) were presented as anticancer drugs. In vitro cytotoxicity assays indicated that these complexes showed anticancer activity against various cancer cells. Flow cytometry and signaling pathways analysis demonstrated that these complexes induced apoptosis via the mitochondrial pathway, as evidenced by the loss of mitochondrial membrane potential and the release of cytochrome c. The resulting accumulation of p53 proteins from phosphorylation at serine-15 and serine-392 was correlated with an increase in p21 and caspase activation. Taken together, these findings suggested that Rul Ru4 may contribute to the future development of improved chemotherapeutics against human cancers. (C) 2013 Elsevier Masson SAS. All rights reserved.