tetralone reductase from Trichosporon capitatum

• 英文名称: tetralone reductase from Trichosporon capitatum

反应信息

• 作为试剂：
  描述：

  6-溴-2-四氢萘酮 在 tetralone reductase from Trichosporon capitatum 聚合甲醛 、 formate dehydrogenase 、 β-烟酰胺腺嘌呤二核苷酸 作用下， 以 乙二醇甲醚 为溶剂， 生成 (2S)-6-溴-1,2,3,4-四氢萘-2-醇
  参考文献：
  名称：

  An alternative bioreactor concept for application of an isolated oxidoreductase for asymmetric ketone reduction

  摘要：

  In this paper an isolated NADH dependent ketone reductase has been used to synthesise (S)-6-bromo-beta-tetralol from 6-bromo-beta-tetralone, together with commercially available formate dehydrogenase (FDH) as a recycle enzyme to produce preparative quantities of the product. Furthermore, initial experiments indicate potential for an alternative bioreactor concept via the use of a resin (XAD L-323) to bind the product (and residual substrate) of the conversion rather than the cofactors or enzymes, thus allowing a new method of recycle, potentially overcoming existing problems. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2003.11.060