squalene---hopene cyclase | 76600-69-6

• 分子结构分类: 异构酶 - 分子内转移酶 - 转移基团
• 英文名称: squalene---hopene cyclase
• 英文别名: Tyr₄₂₀Ala mutant of squalene-hopene cyclase
• CAS: 76600-69-6

反应信息

• 作为试剂：
  描述：

  角鲨烯 在 squalene---hopene cyclase 作用下， 以0.4%的产率得到(17E)-13α(H)-malabarica-14(27),17,21-triene
  参考文献：
  名称：

  Production of bicyclic and tricyclic triterpenes by mutated squalene-hopene cyclase

  摘要：

  Mutagenesis of Tyr420 to Ala in the catalytic cavity of squalene-hopene cyclase of Alicyclobacillus acidocaldarius resulted in an altered product spectrum. Besides hopene and diplopterol, this mutant produced significant amounts of the bicyclic alpha- and gamma-polypodatetraenes and minor amounts of the tricyclic 13 alpha(H)-malabaricatriene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01248-4