Nephroma laevigatum chlorinating enzyme

• 英文名称: Nephroma laevigatum chlorinating enzyme

反应信息

• 作为试剂：
  描述：

  大黄素 在 Nephroma laevigatum chlorinating enzyme potassium dihydrogenphosphate 、 potassium chloride 、 双氧水 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 68.0h， 以30%的产率得到2-氯-1,3,8-三羟基-6-甲基蒽-9,10-二酮
  参考文献：
  名称：

  Chlorination of anthraquinones by lichen and fungal enzymes

  摘要：

  Chlorination of the anthraquinones, emodin and 7-chloroemodin, was studied with an enzyme preparation from the lichen Nephroma laevigatum, and a commerically available fungal chloroperoxidase (EC 1.11.1.10). The fungal enzyme converted emodin to a mixture of 5-chloro, 7-chloro and 5,7-dichloroemodin, while converting the 7-chloro isomer to 5,7-dichloroemodin in nearly quantitative yield. The lichen enzyme, however, chlorinated emodin only at C-7 and failed to chlorinate 7-chloroemodin further. In non-enzymic controls, emodin gave the same set of products as the fungal enzyme but 7-chloroemodin did not undergo further chlorination. The chemical structures of the products were confirmed from UV, EI-mass and H-1 NMR spectral data. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0031-9422(96)00384-6