chlorodicyclohexylphosphine–borane complex | 860466-13-3

• 英文名称: chlorodicyclohexylphosphine–borane complex
• 英文别名: chlorodicyclohexylphosphine-borane complex；dicyclohexylchlorophosphine borane
• CAS: 860466-13-3
• 化学式: C₁₂H₂₅BClP
• 分子量: 246.568
• InChiKey: WVQXVIUYOGMALY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  chlorodicyclohexylphosphine–borane complex 在 吗啉 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 12.0h， 生成 2-((dicyclohexylphosphino)methyl)pyridine
  参考文献：
  名称：

  Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor

  摘要：

  A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.047
• 作为产物：
  描述：

  二环己基氯化膦 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 chlorodicyclohexylphosphine–borane complex
  参考文献：
  名称：

  The Dual Role of Ruthenium and Alkali Base Catalysts in Enabling a Conceptually New Shortcut to N-Unsubstituted Pyrroles through Unmasked α-Amino Aldehydes

  摘要：

  A virtually salt-free and straightforward bimolecular assembly giving N-unsubstituted pyrroles through fully unmasked a-amino aldehydes, which was enabled by the dual effects of a catalytic ruthenium complex and an alkali metal base, is reported. Either solvent-free or acceptorless dehydrogenation facilitates high atom, step, and pot economy, which are otherwise difficult to achieve in multistep operations involving protection/deprotection.

  DOI：

  10.1021/ol4001262

文献信息

• Diarylphosphine- and dialkylphosphine-containing compounds, processes of preparing same and uses thereof as tridentate ligands
  申请人：Technion Research & Development Foundation Ltd.

  公开号：US08318960B2

  公开（公告）日：2012-11-27

  A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing and dialkylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed. Novel precursor molecules useful for preparing the tridentate ligands and processes of preparing same are also disclosed.

  公开了一种制备含有一个或多个二芳基膦和/或二烷基膦电子给体基团的三齿配体的新工艺。公开了使用该工艺制备这种三齿配体和含有同样三齿配体的有机金属配合物的组合化学库。进一步公开了新的含有二芳基膦和二烷基膦的化合物，可以作为三齿配体（例如夹子配体），这种三齿配体的组合化学库，含有这些配体（例如夹子配合物）的有机金属配合物和这些配合物的组合化学库。公开了利用这些库筛选候选有机金属催化剂的方法。还公开了用于制备三齿配体的新前体分子和制备这些分子的工艺。