| 1346518-78-2

• CAS: 1346518-78-2
• 化学式: C₂₅H₁₉FNOP
• 分子量: 399.404
• InChiKey: IXYSKZHYEVAEQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.04
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  3-[Bis(trimethylsilyl)amino]-phenylmagnesium chloride 在 甲醇 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Enantioselective Supramolecular Catalysis Induced by Remote Chiral Diols

  摘要：

  A new method of creating libraries of chiral diphosphines is presented. Supramolecular coordination compounds based on Ti, Rh, achiral ditopic ligands, and chiral diols were synthesized by in situ mixing and used as catalysts in the asymmetric hydrogenation of (Z)-methyl 2-acetamido-3-phenylacrylate, giving ee's of up to 92%. The ditopic ligands contain a Schiff base that coordinates to the assembly metal Ti and a phosphine as a ligand for Rh. Chirality is introduced by coordination of the chiral diols to Ti. The controlling chiral center and the substrate are separated by as much as 13 angstrom.

  DOI：

  10.1021/ja207912d