(2,6-difluoropyrimidin-4-yl)bis(triethyl-l5-phosphaneyl)nickel(IV) fluoride | 256234-36-3

• 英文名称: (2,6-difluoropyrimidin-4-yl)bis(triethyl-l5-phosphaneyl)nickel(IV) fluoride
• CAS: 256234-36-3
• 化学式: C₁₆H₃₁F₃N₂NiP₂
• 分子量: 429.068
• InChiKey: AHGAYQLXAUXXBS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (2,6-difluoropyrimidin-4-yl)bis(triethyl-l5-phosphaneyl)nickel(IV) fluoride 在 CsOH*H₂O 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 2,6-difluoro-4H-pyrimidin-4-ide;2,6-difluoropyrimidin-4-olate;nickel(2+);triethylphosphane
  参考文献：
  名称：

  Nickel-Assisted Carbon-Fluorine Bond Activation of 2,4,6-Trifluoropyrimidine: Synthesis of New Pyrimidine and Pyrimidinone Derivatives

  摘要：

  Rapid and regioselective activation of the C-F bond of 2,4,6-trifluoropyrimidine occurs on reaction with [Ni(cod)(2)] (cod=1,5-cyclooctadiene) in the presence of PEt(3) to give 1, which can be converted into complex 2, containing a further N(3)-metalated pyrimidin-4-one unit. The novel pyrimidin-4-one 3 is released on protonation of 2.

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3326::aid-anie3326>3.0.co;2-7
• 作为产物：
  描述：

  bis(1,5-cyclooctadiene)nickel (0) 、 2,4,6-三氟嘧啶 、 三乙基膦 以 正己烷 为溶剂， 以72%的产率得到(2,6-difluoropyrimidin-4-yl)bis(triethyl-l5-phosphaneyl)nickel(IV) fluoride
  参考文献：
  名称：

  Nickel-Assisted Carbon-Fluorine Bond Activation of 2,4,6-Trifluoropyrimidine: Synthesis of New Pyrimidine and Pyrimidinone Derivatives

  摘要：

  Rapid and regioselective activation of the C-F bond of 2,4,6-trifluoropyrimidine occurs on reaction with [Ni(cod)(2)] (cod=1,5-cyclooctadiene) in the presence of PEt(3) to give 1, which can be converted into complex 2, containing a further N(3)-metalated pyrimidin-4-one unit. The novel pyrimidin-4-one 3 is released on protonation of 2.

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3326::aid-anie3326>3.0.co;2-7