3-(trifluoromethoxy)cyclohex-1-ene | 1241960-11-1

• 英文名称: 3-(trifluoromethoxy)cyclohex-1-ene
• CAS: 1241960-11-1
• 化学式: C₇H₉F₃O
• 分子量: 166.143
• InChiKey: GCKSREMGLSQMLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  三氟甲烷磺酸三氟甲酯 、 3-溴环己烯 在 silver fluoride 作用下， 以 乙腈 为溶剂， 反应 26.5h， 生成 3-(trifluoromethoxy)cyclohex-1-ene
  参考文献：
  名称：

  A deeper insight into direct trifluoromethoxylation with trifluoromethyl triflate

  摘要：

  Commercially available fluorides (silver fluoride and n-tetrabutylammonium triphenyldifluorosilicate), combined with TFMT, allow a simple generation, in situ, of silver and n-tetrabutylammonium trifluoromethoxides which were able to react with electrophilic substrates. Silver trifluoromethoxide, which is usually more efficient than n-tetrabutylammonium trifluoromethoxide, converts, under mild conditions, primary aliphatic bromides and iodides, as well as primary and secondary benzylic or allylic bromides to the corresponding trifluoromethoxylated compounds. Several trifluoromethyl ethers, which could be valuable building-blocks, were prepared in such a way. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2009.11.006