6-(3,4-dichlorophenyl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine | 1234350-42-5

• 英文名称: 6-(3,4-dichlorophenyl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
• 英文别名: 6-(3,4-dichlorophenyl)-N-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
• CAS: 1234350-42-5
• 化学式: C₃₁H₃₁Cl₂N₅
• 分子量: 544.527
• InChiKey: PDRGZLLAEWOLGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  44.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(6-(3,4-Dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate 、 N-甲基哌嗪 以to afford 6-(3,4-dichlorophenyl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine M.p.=119-121° C的产率得到6-(3,4-dichlorophenyl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
  参考文献：
  名称：

  SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS

  摘要：

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病的受试者来治疗癌症等细胞增殖性疾病的方法。

  公开号：

  US20100239525A1

文献信息

• Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
  申请人：Ali Syed

  公开号：US08357694B2

  公开（公告）日：2013-01-22

  The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的制药组合物，以及通过将这些化合物和制药组合物用于需要治疗细胞增殖性疾病，如癌症的受试者来治疗的方法。
• US8357694B2
  申请人：——

  公开号：US8357694B2

  公开（公告）日：2013-01-22
• [EN] SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS DE 5,6-DIHYDRO-6-PHÉNYLBENZO[F]ISOQUINOLÉINE-2-AMINES SUBSTITUÉES
  申请人：ARQULE INC

  公开号：WO2010078421A1

  公开（公告）日：2010-07-08

  The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.