bis-(4-isopropoxyphenyl)-phosphine borane | 1198309-54-4

• 英文名称: bis-(4-isopropoxyphenyl)-phosphine borane
• CAS: 1198309-54-4
• 化学式: C₁₈H₂₆BO₂P
• 分子量: 316.188
• InChiKey: YLQDDRGCCKCKOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  bis-(4-isopropoxyphenyl)-phosphine borane 、 二苯基乙炔 在 sodium hydride 作用下， 以 N,N-二甲基乙酰胺 、 mineral oil 为溶剂， 以78%的产率得到
  参考文献：
  名称：

  Ambient Temperature Hydrophosphination of Internal, Unactivated Alkynes and Allenyl Phosphineoxides with Phosphine Borane Complexes

  摘要：

  Phosphine boranes have been found to hydrophosphinate internal, unactivated alkynes at room temperature under basic conditions without the need for catalysts or radical initiators, The use of air-sensitive secondary phosphines is avoided in this facile process. Broad scope in both the phosphine borane and alkyne partners leads to excellent diversity in the phosphine products. Asymmetric hydrogenation of these species then provides one of the shortest possible routes to chiral monodentate phosphines, Hydrophosphination of allenyl phosphine oxides under similar conditions followed by hydrogenation of the exomethylene moiety yields a wide variety of bis-phosphine derivatives.

  DOI：

  10.1021/ol9022547
• 作为产物：
  描述：

  在 二异丁基氢化铝 、 硼烷四氢呋喃络合物 、 sodium hydroxide 作用下， 以 甲苯 、 水 为溶剂， -78.0~20.0 ℃ 、2.67 kPa 条件下， 反应 1.0h， 以60%的产率得到bis-(4-isopropoxyphenyl)-phosphine borane
  参考文献：
  名称：

  Ambient Temperature Hydrophosphination of Internal, Unactivated Alkynes and Allenyl Phosphineoxides with Phosphine Borane Complexes

  摘要：

  Phosphine boranes have been found to hydrophosphinate internal, unactivated alkynes at room temperature under basic conditions without the need for catalysts or radical initiators, The use of air-sensitive secondary phosphines is avoided in this facile process. Broad scope in both the phosphine borane and alkyne partners leads to excellent diversity in the phosphine products. Asymmetric hydrogenation of these species then provides one of the shortest possible routes to chiral monodentate phosphines, Hydrophosphination of allenyl phosphine oxides under similar conditions followed by hydrogenation of the exomethylene moiety yields a wide variety of bis-phosphine derivatives.

  DOI：

  10.1021/ol9022547