difluoro-(3-bromopentan-2,4-dionato)-Boron | 67940-38-9

• 英文名称: difluoro-(3-bromopentan-2,4-dionato)-Boron
• 英文别名: boron 2,2-difluoro-5-bromo-4,6-dimethyl-1,3,2-dioxaborin
• CAS: 67940-38-9
• 化学式: C₅H₆BBrF₂O₂
• 分子量: 226.813
• InChiKey: QVWLQQJNIJOVRQ-UHFFFAOYSA-N

物化性质

• 熔点：
  109-110 °C(Solv: hexane (110-54-3))

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  difluoro-(3-bromopentan-2,4-dionato)-Boron 在 盐酸肼 、 氨 作用下， 以 乙醇 、 水 为溶剂， 反应 0.67h， 生成 4-氯-3,5-二甲基-1H-吡唑 、 3,5-二甲基-4-溴吡唑
  参考文献：
  名称：

  α-substituted boron difluoride acetylacetonates

  摘要：

  By treatment of a-substituted acetylacetone derivatives with boron trifluoride etherate a series of earlier unknown boron difluoride complexes is obtained. The series includes binuclear complexes containing boron in the chelate fragment connected via sulfur or selenium atom. Gas chromatographic and spectral characteristics of the obtained compounds were investigated. By means of chromato-mass spectrometry their reaction with hydrazine in acidic and alkaline media was studied.

  DOI：

  10.1134/s1070363208080094
• 作为产物：
  描述：

  HacacBr 在 硼酸三丁酯 、 三氟化硼乙醚 作用下， 反应 24.0h， 以95%的产率得到difluoro-(3-bromopentan-2,4-dionato)-Boron
  参考文献：
  名称：

  α-substituted boron difluoride acetylacetonates

  摘要：

  By treatment of a-substituted acetylacetone derivatives with boron trifluoride etherate a series of earlier unknown boron difluoride complexes is obtained. The series includes binuclear complexes containing boron in the chelate fragment connected via sulfur or selenium atom. Gas chromatographic and spectral characteristics of the obtained compounds were investigated. By means of chromato-mass spectrometry their reaction with hydrazine in acidic and alkaline media was studied.

  DOI：

  10.1134/s1070363208080094

文献信息

• 姜黄素硼配合物和含有该姜黄素硼配合物的 药物
  申请人：国立研究开发法人科学技术振兴机构

  公开号：CN108884112B

  公开（公告）日：2021-03-02

  本发明提供可应用于生物体内、且为淀粉样蛋白选择性的、作为不仅能够适用于Aβ肽还能够适用于其它淀粉样蛋白的淀粉样蛋白氧合催化剂有用的化合物和使用该化合物的淀粉样蛋白相关疾病预防治疗药。一种以下的通式(1)表示的姜黄素硼配合物或其盐(式中，X1和X2相同或不同，且表示卤代烷基或卤素原子；X3表示溴原子、碘原子或硒原子；R1和R2相同或不同，且表示氢原子或可具有取代基的烷基；R3和R4相同或不同，且表示氢原子、卤素原子、烷氧基或可具有取代基的烷基，或者R1和R3、或R2和R4可以一起形成可具有取代基的亚烷基或亚烯基；R5和R6相同或不同，且表示氢原子或可具有取代基的烷基；R7和R8相同或不同，且表示氢原子、卤素原子、烷氧基或可具有取代基的烷基，或者R5和R7、或R6和R8可以一起形成可具有取代基的亚烷基或亚烯基；m和n表示1～3的整数)。
• CURCUMIN-BORON COMPLEX AND PHARMACEUTICAL CONTAINING SAME
  申请人：Japan Science and Technology Agency

  公开号：EP3434681A1

  公开（公告）日：2019-01-30

  Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.

  提供的是一种生物适用且选择性作用于淀粉样蛋白的化合物，可作为淀粉样蛋白氧化催化剂，不仅适用于Aβ肽还适用于其他淀粉样蛋白，并且可用于预防/治疗淀粉样蛋白相关疾病的药物。以下是由姜黄素硼复合物表示的化学式（1）：其中X1和X2相同或不同，每个代表卤代烷基或卤素原子；X3代表溴原子、碘原子或硒原子；R1和R2相同或不同，每个代表氢原子或可选择取代的烷基；R3和R4相同或不同，每个代表氢原子、卤素原子、烷氧基或可选择取代的烷基，或者R1和R3或R2和R4可选择结合形成可选择取代的烷基烃基或烯基烃基；R5和R6相同或不同，每个代表氢原子或可选择取代的烷基；R7和R8相同或不同，每个代表氢原子、卤素原子、烷氧基或可选择取代的烷基，或者R5和R7或R6和R8可选择结合形成可选择取代的烷基烃基或烯基烃基；m和n各自表示1到3的整数，或其盐。
• Shapkin, N. P.; Korotkikh, O. A.; Karasev, V. E., Russian Journal of Inorganic Chemistry, 1985, vol. 30, p. 1069 - 1070
  作者：Shapkin, N. P.、Korotkikh, O. A.、Karasev, V. E.

  DOI：——

  日期：——