N-phthalimide-N(in)-formyl l-tryptophanyl chloride | 855310-87-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-phthalimide-N(in)-formyl l-tryptophanyl chloride
• CAS: 855310-87-1
• 化学式: C₂₀H₁₃ClN₂O₄
• 分子量: 380.787
• InChiKey: OZWNEEDJYSIVJF-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.45
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N-phthalimide-N(in)-formyl l-tryptophanyl chloride 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 tetraethyl 2-N-phthalimide-3-(N-formylindole)-1-hydroxypropylidene-1,1-bisphosphonate
  参考文献：
  名称：

  α-AMINO ACID DERIVED BISPHOSPHONATES. SYNTHESIS AND ANTI-RESORFTIVE ACTIVITY

  摘要：

  Eleven new bisphosphonates were prepared from naturally-occurring I-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-induced hypercalcemia and were compared to alendronate. Most of the compounds showed moderate to no anti-resorptive activity. Two compounds were more active than clodronate, but less than alendronate. Limited SAR conclusions were drawn.

  DOI：

  10.1080/10426500108045257
• 作为产物：
  描述：

  N-phthalimide-N(in)-formyl l-tryptophane 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以93%的产率得到N-phthalimide-N(in)-formyl l-tryptophanyl chloride
  参考文献：
  名称：

  α-AMINO ACID DERIVED BISPHOSPHONATES. SYNTHESIS AND ANTI-RESORFTIVE ACTIVITY

  摘要：

  Eleven new bisphosphonates were prepared from naturally-occurring I-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-induced hypercalcemia and were compared to alendronate. Most of the compounds showed moderate to no anti-resorptive activity. Two compounds were more active than clodronate, but less than alendronate. Limited SAR conclusions were drawn.

  DOI：

  10.1080/10426500108045257