3-n-propyl-1,2,4,5-tetraoxaspiro[5.5]undecane | 1262765-14-9

• 英文名称: 3-n-propyl-1,2,4,5-tetraoxaspiro[5.5]undecane
• 英文别名: 3-Propyl-1,2,4,5-tetraoxaspiro[5.5]undecane
• CAS: 1262765-14-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: CYASALFKOMVOEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,1-二乙氧基环己烷 、 1,1-dihydroperoxybutane 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以50%的产率得到3-n-propyl-1,2,4,5-tetraoxaspiro[5.5]undecane
  参考文献：
  名称：

  Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides

  摘要：

  A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.151