bis-[di-(3,5-dimethoxyphenyl)methylcyclopentadienyl] titanium(IV) dichloride | 905280-37-7

• 英文名称: bis-[di-(3,5-dimethoxyphenyl)methylcyclopentadienyl] titanium(IV) dichloride
• 英文别名: (η(5)-C5H4-CH-[C6H3-(OCH3)2]2)2TiCl2
• CAS: 905280-37-7
• 化学式: C₄₄H₄₆Cl₂O₈Ti
• 分子量: 821.63
• InChiKey: QBOSPHZRMLSVID-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 拓扑面积：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  (3,5-dimethoxylphenyl)lithium 、 3,5-dimethoxyphenylfulvene 、 四氯化钛 以 四氢呋喃 、 甲苯 为溶剂， 以43.5%的产率得到bis-[di-(3,5-dimethoxyphenyl)methylcyclopentadienyl] titanium(IV) dichloride
  参考文献：
  名称：

  Diarylmethyl substituted titanocenes: Promising anti-cancer drugs

  摘要：

  From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanityl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a-c). Titanium tetrachloride was added "in situ", obtaining titanocenes 5a-C, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) Of 3.8 x 10(-5) M, 4.5 x 10(-5) M, and 7.8 x 10(-5) M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2006.01.007