{(η6-hexamethylbenzene)2Fe}{CoCl4} | 138417-03-5

• 英文名称: {(η6-hexamethylbenzene)2Fe}{CoCl4}
• CAS: 138417-03-5
• 化学式: C₂₄H₃₆Fe*Cl₄Co
• 分子量: 581.202
• InChiKey: UUNCWLJEHWWOMW-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [(η6-hexamethylbenzene)2Fe][PF6]2 、 cobalt(II) chloride 以 丙酮 为溶剂， 以61%的产率得到{(η6-hexamethylbenzene)2Fe}{CoCl4}
  参考文献：
  名称：

  Studies on the anti-tumour activity of some iron sandwich compounds

  摘要：

  Four types of water-soluble iron sandwich compounds, ferrocenes bearing charged side chains (Ia), ferrocenium salts (Ib). (eta-arene)2Fe2+ salts (II) and (eta-arene)(eta-cyclopentadienyl)Fe+ salts (III), have been tested in vitro against experimental tumours, L1210, Walkers and Chinese hamster lung (V.79). Some activity was observed for all the types of complex; though that of only two, Ib and II, was good. Of special interest is that the iron(II) sandwich type II compounds display anti-tumour activity, since previous active complexes have contained type Ib or other known cytotoxic groups that would account for their activity. Examples of complexes of type Ib and II were further tested against improved cell lines L1210, PC6 and CH1. The results show the two types to be similar in their effect and specificity. An attempt is made to rationalise the data.

  DOI：

  10.1016/0022-328x(91)86350-y